PP028. Serum cytokine profile in relation to the clinical features and laboratory parameters in women with preeclampsia

Molvarec, Attila; Szarka, András; Lázár, Levente; Rigó, János

doi:10.1016/j.preghy.2013.04.055

Cited by 3 publications

(2 citation statements)

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“…IL-4 is a potent factor that directs differentiation of naive Th cells (Th0 cells) into Th2 cells (Chen et al, 2004), and decreases the production of Th1 cells and IFN-γ (Sokol et al, 2008). It has been reported that a shift towards Th1-type immunity (increase in IL-2/IL-4 and IFN-γ/IL-4 ratios) in women with preeclampsia (Molvarec et al, 2013). We found that the relative levels of IL-4 mRNA and protein were lower in pregnant groups (Fig.…”

Section: Discussionmentioning

confidence: 99%

Differential expression of T helper cytokines in the liver during early pregnancy in sheep

Yang¹,

Bai²,

Zhao³

et al. 2019

Anim Reprod

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Liver plays important roles in the innate and adaptive immunity, and contributes to the maternal immune adjustments during pregnancy in mice and rats. T helper 1 (Th1) and Th2 cytokines are related to immune response. However, expression of Th1 and Th2 cytokines in maternal livers is unclear during early pregnancy in sheep. In this study, livers were collected on day 16 of the estrous cycle and on days 13, 16 and 25 of pregnancy (n = 6 for each group) in ewes, and qRT-PCR, western blot and immunohistochemistry were used to analyze the expression of Th1 and Th2 cytokines in the livers. Our results showed that interferon-gamma (IFN-γ), interleukin (IL)-2, IL-4, IL-6 and IL-10 were downregulated, and IL-5 was upregulated in the livers during early pregnancy. Furthermore, there was no effect for early pregnancy on expression of TNF-β in the livers, and the IFN-γ protein was limited to the endothelial cells of the proper hepatic arteries and portal veins. In conclusion, early pregnancy exerted its effect on the liver to regulate the Th cytokines expression, but there was no evident shift from Th1 to Th2 cytokines, which may be necessary for the maternal hepatic immune adjustments during early pregnancy in sheep.

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Section: Discussionmentioning

confidence: 99%

Differential expression of T helper cytokines in the liver during early pregnancy in sheep

Yang¹,

Bai²,

Zhao³

et al. 2019

Anim Reprod

View full text Add to dashboard Cite

show abstract

“…Elevations of specific cytokines have been inconsistently reported in preeclampsia, and the origins of such elevations are not known [28]. Cytokines are not invalid markers of immune function, but their transiency and susceptibility to environmental influences may significantly affect their quantification [28].…”

Section: Findings Tregs In Pregnancymentioning

confidence: 99%

T Receptor Lymphocytes - Can they be Used as a Low Cost Predictive Tool for Dysfunctional Placental Diseases?

Sengupta¹,

Tan²,

Chaouat³

2016

Ann Clin Lab Res

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Background: Regulatory T cells (Tregs) are lymphocytes originating in the bone marrow. They mature in the thymus and help fight inflammation in humans. Tregs are involved in the maternal acceptance of the allogeneic fetus.Objectives: This review focuses on the role of Tregs i.e. the origins, development and function in pregnancy, as well as their diagnostic and therapeutic value in pregnancy pathologies such as miscarriage and preeclampsia (PE).Methods: A MeSH and text word PubMed search through August 2016 was performed using the keywords: T receptor lymphocytes; subsets of regulatory T cells: regulatory T cells; controlled trials; pregnancy and treatment. Additional databases searched included; Google scholar, database of abstracts of reviews of effects (DARE),Cochrane Library, NIHR central portfolio management system, UK database of uncertainties about the effects of treatments (DUETs), trip database, health on the NET Northern Ireland (HONNI), the knowledge network Scotland, the Geneva foundation for medical education and research (GFMER) and ClinicalTrials.gov. Findings and conclusions:The origins, development, function and the role of Tregs in the pathophysiology of pregnancy and its complications have not been fully clarified. A lack of Treg cells or defective production due to placental disease or an altered immune response are found in women with sub-fertility, recurrent miscarriage, PE and preterm birth. However, clinical studies to date have involved small numbers of women (with a paucity of randomized controlled trials). Future research focusing on Tregs and their diagnostic and therapeutic value in the management of pregnancy complications are urgently needed.

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The role of the IL-1 system in pregnancy and the use of IL-1 system markers to identify women at risk for pregnancy complications†

Equils¹,

Kellogg

McGregor³

et al. 2020

Biology of Reproduction

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Abstract The interleukin (IL)-1 system plays a major role in immune responses and inflammation. The IL-1 system components include IL-1α, IL-1β, IL-1 receptor type 1 and IL-1 receptor type 2 (decoy receptor), IL-1 receptor accessory protein, and IL-1 receptor antagonist (IL-1Ra). These components have been shown to play a role in pregnancy, specifically in embryo-maternal communication for implantation, placenta development, and protection against infections. As gestation advances, maternal tissues experience increasing fetal demand and physical stress and IL-1β is induced. Dependent on the levels of IL-1Ra, which regulates IL-1β activity, a pro-inflammatory response may or may not occur. If there is an inflammatory response, prostaglandins are synthesized that may lead to myometrial contractions and the initiation of labor. Many studies have examined the role of the IL-1 system in pregnancy by independently measuring plasma, cervical, and amniotic fluid IL-1β or IL-1Ra levels. Other studies have tested for polymorphisms in IL-1β and IL-1Ra genes in women experiencing pregnancy complications such as early pregnancy loss, in vitro fertilization failure, pre-eclampsia and preterm delivery. Data from those studies suggest a definite role for the IL-1 system in successful pregnancy outcomes. However, as anticipated, the results varied among different experimental models, ethnicities, and disease states. Here, we review the current literature and propose that measurement of IL-1Ra in relation to IL-1 may be useful in predicting the risk of poor pregnancy outcomes.

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PP028. Serum cytokine profile in relation to the clinical features and laboratory parameters in women with preeclampsia

Cited by 3 publications

References 0 publications

Differential expression of T helper cytokines in the liver during early pregnancy in sheep

Differential expression of T helper cytokines in the liver during early pregnancy in sheep

T Receptor Lymphocytes - Can they be Used as a Low Cost Predictive Tool for Dysfunctional Placental Diseases?

The role of the IL-1 system in pregnancy and the use of IL-1 system markers to identify women at risk for pregnancy complications†

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