2022
DOI: 10.1097/01.pcc.0000900236.12522.0c
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PP076 [Combined Organ Systems » Renal / Electrolytes imbalance]: RESTRICTED VERSUS LIBERAL MAINTENANCE FLUID STRATEGY IN MECHANICALLY VENTILATED CHILDREN: AN OPEN-LABEL RANDOMIZED TRIAL

Abstract: combined with sepsis was 0.841 (P<0.001, 95%CI 0.750-0.932), and there was no statistical significance in AU-ROC compared with pSOFA(Z =0.406, P=0.6845> 0.05). In 36 non-survival and 58 survival, non-survival group had more significant reduction of Hb and PLT, more serious damage of organ functions, and higher incidence of SF>4500 ng/ mL. The incidence of sepsis was higher in the non-survival group (52.8%, 19/36) than in the survival group (8.6%, 5/58) (P<0.05). Multivariate analysis showed that sepsis, PLT< 5… Show more

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“…Unfortunately, no pediatric counterpart of such a large multicenter study in the PICU has been performed to date. Two small, single-center pilot randomized controlled studies among mechanically ventilated children showed limited effect on cumulative fluid balance by restricting fluid intake to 40-70% of calculated normal maintenance fluids [77,78]. In a pilot study that compared a historical cohort with a prospective quality improvement fluid bundle including early use of diuretics, Diaz et al report a substantial reduction of fluid overload in children with acute respiratory distress syndrome and sepsis [79].…”
Section: Maintenance Fluid Therapy and Evacuation: The Stabilization ...mentioning
confidence: 99%
“…Unfortunately, no pediatric counterpart of such a large multicenter study in the PICU has been performed to date. Two small, single-center pilot randomized controlled studies among mechanically ventilated children showed limited effect on cumulative fluid balance by restricting fluid intake to 40-70% of calculated normal maintenance fluids [77,78]. In a pilot study that compared a historical cohort with a prospective quality improvement fluid bundle including early use of diuretics, Diaz et al report a substantial reduction of fluid overload in children with acute respiratory distress syndrome and sepsis [79].…”
Section: Maintenance Fluid Therapy and Evacuation: The Stabilization ...mentioning
confidence: 99%