2019
DOI: 10.1091/mbc.e18-10-0631
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PP2A-B55/SUR-6 collaborates with the nuclear lamina for centrosome separation during mitotic entry

Abstract: Across most sexually reproducing animals, centrosomes are provided to the oocyte through fertilization and must be positioned properly to establish the zygotic mitotic spindle. How centrosomes are positioned in space and time through the concerted action of key mitotic entry biochemical regulators, including protein phosphatase 2A (PP2A-B55/SUR-6), biophysical regulators, including dynein, and the nuclear lamina is unclear. Here, we uncover a role for PP2A-B55/SUR-6 in regulating centrosome separation. Mechani… Show more

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Cited by 17 publications
(19 citation statements)
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“…, 2015 ; De Simone et al. , 2016 ; Boudreau et al. , 2019 ) and at the cell cortex ( Cytrynbaum et al.…”
Section: Introductionmentioning
confidence: 99%
“…, 2015 ; De Simone et al. , 2016 ; Boudreau et al. , 2019 ) and at the cell cortex ( Cytrynbaum et al.…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, our work reveals that decreasing PP2A functionality increases centrosome clustering. This observation together with the identification of a role for PP2A-B55/SUR-6 in regulating centrosome separation during mitotic entry (Boudreau et al., 2019) opens new avenues of exploration for a role of PP2A in the regulation of centrosome clustering. Our data also suggest that fine-tuning phosphoregulation, in the form of a heterozygous PP2A-Aα mutation, allows a human cell to become more proficient at centrosome clustering without compromising mitotic fidelity.…”
Section: Discussionmentioning
confidence: 95%
“…Strikingly, PP2A has also been shown in C. elegans embryos to later further oppose Plk1 and Aurora A function on the centrosomes to promote the disassembly of the pericentriolar material (PCM) as cells exit mitosis, thereby decreasing microtubule nucleation [44]. Finally, and besides these functions in centrosome duplication, the PP2A phosphatase, in a heterotrimeric complex with its associated B55/ SUR-6 adaptor subunits, was found to act in collaboration with the nuclear lamina to promote centrosome separation during mitotic entry [45]. Therefore, PP2A activity on the spindle MTOCs must be precisely and differentially regulated to act on diverse substrates and thus to carry out unique functions at different cell cycle stages.…”
Section: The Mtocs In the Regulation Of Cell Cycle Progressionmentioning
confidence: 93%