2006
DOI: 10.1111/j.1349-7006.2006.00219.x
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PP2C family members play key roles in regulation of cell survival and apoptosis

Abstract: U nlimited proliferation is typical of cancer cells, a phenotype supported by several distinct biological events, including enhanced cell proliferation, increased cell survival, and decreased cell death. Studies examining the molecular bases of these events have identified a variety of signaling pathways that are involved in their regulation. The mechanisms by which these different signaling pathways are coordinated to regulate proliferation and survival of cancer cells has remained poorly understood.ROS are n… Show more

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Cited by 85 publications
(85 citation statements)
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“…31 Several phosphatases that dephosphorylate some of these sites have been identified. Serine/threonine protein phosphatase type 5 (PP5) and PP2C dephosphorylate phosphorylated (p)-Thr-838, 28,32 whereas PP2A and SHP2 dephosphorylate p-Ser-967 and p-Tyr-718, respectively. 31,33 Little is known about the kinase or phosphatase that regulates phosphorylation at Ser-1034.…”
mentioning
confidence: 99%
“…31 Several phosphatases that dephosphorylate some of these sites have been identified. Serine/threonine protein phosphatase type 5 (PP5) and PP2C dephosphorylate phosphorylated (p)-Thr-838, 28,32 whereas PP2A and SHP2 dephosphorylate p-Ser-967 and p-Tyr-718, respectively. 31,33 Little is known about the kinase or phosphatase that regulates phosphorylation at Ser-1034.…”
mentioning
confidence: 99%
“…BAD phosphorylation is maintained by growth factor signaling, and withdrawal of growth factors leads to dephosphorylation of BAD and the activation of the intrinsic mitochondrial pathway (28,34). Several protein phosphatases have been implicated in BAD dephosphorylation, including PP1␣ (35-37), PP2A (38), PP2B (39), and PP2C (40). Caspase-9 activation also has been reported to be dependent on PP1␣ activity (41).…”
Section: S6kmentioning
confidence: 99%
“…[4][5][6] Phosphorylation occurs rapidly, controls almost all cellular processes, and is sufficiently stable and distinct as a chemical entity that antibody reagents can be developed to recognize the presence or absence of phosphorylation on proteins or lipids. Using antibodies against phosphorylated proteins researchers have mapped numerous cell-signaling pathologies related to cancer, as well as demonstrated the molecular entities and mutations driving their function.…”
Section: Phosphoproteins As Accessible Measures Of Signaling Status Imentioning
confidence: 99%