Pp54. Nano-Encapsulated Disulfiram Targets Glioblastoma Stem Cells in Vitro and in Vivo by Modulation of Hypoxia-Nf-Kb Pathway

Kannappan, D. V.; Wang, D. Z.; Liu, D. P.; Brown, David; Butcher, Martin; Azar, Michelle; Bian, Pan; Armesilla, D. A.; Darling, Peter; Wang, P. W.

doi:10.1093/neuonc/now293.054

Cited by 2 publications

(1 citation statement)

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“…Integrin-mediated signaling pathways have been found to promote the invasiveness and survival of glioma cells in brain microenvironment, more concretely they support the formation of the tumoral niche [151]. As such, integrins are a promise targeting for GB treatment due to their implication in tumor cell functions and their interaction with several pathways, including MAP kinase, Jun, NF-κB, and their location at the TME [110,145,152,153].…”

Section: Glioblastomamentioning

confidence: 99%

Targeted Theranostic Nanoparticles for Brain Tumor Treatment

et al. 2018

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The poor prognosis and rapid recurrence of glioblastoma (GB) are associated to its fast-growing process and invasive nature, which make difficult the complete removal of the cancer infiltrated tissues. Additionally, GB heterogeneity within and between patients demands a patient-focused method of treatment. Thus, the implementation of nanotechnology is an attractive approach considering all anatomic issues of GB, since it will potentially improve brain drug distribution, due to the interaction between the blood–brain barrier and nanoparticles (NPs). In recent years, theranostic techniques have also been proposed and regarded as promising. NPs are advantageous for this application, due to their respective size, easy surface modification and versatility to integrate multiple functional components in one system. The design of nanoparticles focused on therapeutic and diagnostic applications has increased exponentially for the treatment of cancer. This dual approach helps to understand the location of the tumor tissue, the biodistribution of nanoparticles, the progress and efficacy of the treatment, and is highly useful for personalized medicine-based therapeutic interventions. To improve theranostic approaches, different active strategies can be used to modulate the surface of the nanotheranostic particle, including surface markers, proteins, drugs or genes, and take advantage of the characteristics of the microenvironment using stimuli responsive triggers. This review focuses on the different strategies to improve the GB treatment, describing some cell surface markers and their ligands, and reports some strategies, and their efficacy, used in the current research.

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