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Globus, Tatiana; Woolard, Dwight L.; Khromova, T.; Crowe, T.W.; Bykhovskaia, Maria; Gelmont, Boris; Hesler, Jeffrey L.; Samuels, Alan C.

doi:10.1023/a:1024420104400

Cited by 196 publications

(69 citation statements)

References 26 publications

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“…Further the observed aneuploidy appeared to be chromosomespecific in agreement with other studies on cellular response induced by chemical or physical stimuli [45]. The authors suggested, as possible mechanism underlying these effects, that THz radiation is able to excite low-frequency collective vibrational modes of biomolecules [45]. Recently the coherent collective vibration models of molecule (e.g., DNA and proton) have been theoretical analysed, indicating that the interaction between these biological systems and THz radiation can produce resonance excitation effect capable to explain mutagenesis effects [46].…”

Section: Thz Radiation Effects On Biological Systemssupporting

confidence: 91%

“…2 h) than above done. Further the observed aneuploidy appeared to be chromosomespecific in agreement with other studies on cellular response induced by chemical or physical stimuli [45]. The authors suggested, as possible mechanism underlying these effects, that THz radiation is able to excite low-frequency collective vibrational modes of biomolecules [45].…”

Section: Thz Radiation Effects On Biological Systemssupporting

confidence: 89%

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Terahertz Radiation Effects and Biological Applications

Orlando

Gallerano

2009

J Infrared Milli Terahz Waves

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We present a brief overview of the literature on biological applications and experimental data on the effects of THz radiation. The region of the electromagnetic spectrum from 0.1 to 10 THz is a frontier area for research in physics, chemistry, biology, materials science and medicine. This area has recently begun to be filled by a variety of sources of high quality radiation with a wide range of new technologies related to it. New sources have led to new science in many areas, as scientists begin to become aware of the opportunities for research progress in their fields using THz radiation. Therefore the opportunities for THz science in chemistry and biology are wide ranging. Some of them will extend the range of already established work, many others have not yet been realized but show great promise, and the rest fall somewhere in between.

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Section: Thz Radiation Effects On Biological Systemssupporting

confidence: 91%

Section: Thz Radiation Effects On Biological Systemssupporting

confidence: 89%

Terahertz Radiation Effects and Biological Applications

Orlando

Gallerano

2009

J Infrared Milli Terahz Waves

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“…Far-infrared absorption spectroscopy in the terahertz frequency range provides another access to the low-frequency vibrational excitations of DNA. Besides Fourier-transform spectroscopy [9][10][11] and absorption spectroscopy using tunable terahertz light sources, 12,13 time-domain terahertz spectroscopy became available recently to study optical properties of biomolecules and DNA. [14][15][16][17] In this letter, we use a recently developed terahertz spectrometer based on high-speed asynchronous optical sampling ͑ASOPS͒ to measure the terahertz transmission characteristics of highly oriented wet-spun DNA films.…”

Section: -4mentioning

confidence: 99%

Hydration dynamics of oriented DNA films investigated by time-domain terahertz spectroscopy

Kistner

André

Fischer

et al. 2007

Applied Physics Letters

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The B to A conformational transition of highly oriented DNA films due to a hydration change is observed with time-domain terahertz spectroscopy. Wet-spun films of calf thymus and salmon DNA are investigated for different film thicknesses and for different polarizations of the terahertz radiation relative to the DNA orientation. A clear polarization dependence is observed. Asynchronous optical sampling allows recording of terahertz absorption and background spectra in a few 10 s, permitting the tracking of the dehydration dynamics on a time scale of minutes. The observation of a phase transition is corroborated by Raman spectroscopy. © 2007 American Institute of Physics. ͓DOI: 10.1063/1.2743401͔The conformation of DNA is directly linked to important biological processes such as DNA replication and DNA repair. While DNA in aqueous solution is predominantly in the B form, it is also frequently seen to deviate from this conformation. Dehydration of B-type DNA to below 30% water content by weight converts it into A-type DNA. This conformational transition and its origins in terms of free energy difference between A-and B-type conformations have been intensively studied theoretically 1 and experimentally, e.g., by x-ray diffraction. 2-4Low-frequency vibrational excitations are expected to play an important role in conformational dynamics of DNA, as well as in the hydration shell, and might influence the dynamics of drug binding. 5 In particular, Raman and Brillouin scattering 6,7 as well as thermal neutron scattering 8 have been used to observe low-frequency excitation spectra. Far-infrared absorption spectroscopy in the terahertz frequency range provides another access to the low-frequency vibrational excitations of DNA. Besides Fourier-transform spectroscopy 9-11 and absorption spectroscopy using tunable terahertz light sources, 12,13 time-domain terahertz spectroscopy became available recently to study optical properties of biomolecules and DNA. [14][15][16][17] In this letter, we use a recently developed terahertz spectrometer based on high-speed asynchronous optical sampling ͑ASOPS͒ to measure the terahertz transmission characteristics of highly oriented wet-spun DNA films. We describe the dependences of the terahertz absorption in the range of 100 GHz-2.0 THz on the degree of hydration. Here, we take advantage of the fast sampling possibilities that are inherent to the ASOPS technique. The results from the terahertz experiments are corroborated by x-ray diffraction and Raman scattering experiments.Highly oriented films are produced from DNA sodium salt ͑Sigma-Aldrich Co.͒ using the wet-spinning method developed by Rupprecht. 18 A highly concentrated DNA solution is pumped through a spinneret and precipitated in 77% ethanol solution containing 0.3M NaCl at a temperature of 5°C such that thin DNA fibers are generated and spooled onto a rotating cylinder. Multilayered DNA films are taken off the cylinder and are dried at 5°C and are rehydrated at 75% relative humidity ͑r.h.͒ at room temperature for at least three d...

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“…Millimeter and submillimeter wave region of electromagnetic (EM) spectrum is traditionally utilized in the astrophysics, remote sensing, defense and security, as well as in biomedical imaging applications [1][2][3][4]. Recently, there is an increased interest in utilization of these frequencies in a range of commercial applications, including broadband communications, motivated mainly by the availability of large bandwidths required for the multigigabit short-range wireless communications [5].…”

Section: Introductionmentioning

confidence: 99%

Graphene-based waveguide resonators for submillimeter-wave applications

Ilić

Bukvic

Ilić

et al. 2016

J. Phys. D: Appl. Phys.

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Abstract. Utilization of graphene covered waveguide inserts to form tunable waveguide resonators is theoretically explained and rigorously investigated by means of full-wave numerical electromagnetic simulations. Instead of using graphene based switching elements, the concept we propose incorporates graphene sheets as parts of a resonator. Electrostatic tuning of the graphene surface conductivity leads to changes in the electromagnetic field boundary conditions at the resonator edges and surfaces, thus producing an effect similar to varying electrical length of a resonator. Presented outline of the theoretical background serves to give phenomenological insight into the resonator behavior, but it can also be used to develop customized software tools for design and optimization of graphene based resonators and filters. Due to the linear dependence of the imaginary part of the graphene surface impedance on frequency, the proposed concept was expected to become effective for frequencies above 100 GHz, which is confirmed by the numerical simulations. Frequency range from 100 GHz up to 1100 GHz, where the rectangular waveguides are used, is considered. Simple, all-graphene based resonators are analyzed first, to assess the achievable tunability and to check the performance throughout the considered frequency range. Graphene-metal combined waveguide resonators are proposed in order to preserve excellent quality factors typical for the type of waveguide discontinuities used. Dependence of resonator properties on key design parameters is studied in detail. Dependence of resonator properties throughout the frequency range of interest is studied using eight different waveguide sections appropriate for different frequency intervals. Proposed resonators are aimed at applications in the submillimeter-wave spectral region, serving as the compact tunable components for the design of bandpass filters and other devices.

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Untitled

Cited by 196 publications

References 26 publications

Terahertz Radiation Effects and Biological Applications

Terahertz Radiation Effects and Biological Applications

Hydration dynamics of oriented DNA films investigated by time-domain terahertz spectroscopy

Graphene-based waveguide resonators for submillimeter-wave applications

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