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Physiological Metrology

“…This determines considerable differences between ethnic populations with respect to the N-acetyltransferase phenotypic composition resulting from long-term migrations and natural selection. There are data on ethnic differences in the functions of individual enzymatic systems that are clinically and pharmacogenetically important [6,7]. We demonstrated that ethnic groups differing in the frequency of the fast N-acetylation phenotype differ also in predisposition to some diseases [5][6][7].…”

“…The ethnic predisposition of some populations to tumor formation corresponds to and depends on their metabolic status [6].…”

“…There are data on ethnic differences in the functions of individual enzymatic systems that are clinically and pharmacogenetically important [6,7]. We demonstrated that ethnic groups differing in the frequency of the fast N-acetylation phenotype differ also in predisposition to some diseases [5][6][7]. It was recently hypothesized that predisposition to various diseases is related to the individual activity of N-acetyltransferase 2 (NAT2), a genetically determined system responsible for the detoxification of xenobiotics.…”

Feasibility of Novel Atomic-Molecular Resuscitation Tools

“…The fundamental sciences make untiring efforts to develop novel approaches to the therapy of various pathological states [1][2][3][4]. Among them, of particular interest is application of such diagnostic tools as nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR), which are widely spread in practical medicine.…”

The search for biochemical predictors of the NAT2 phenotype to optimize prophylaxis and pharmacotherapy of hepatic cirrhosis

“…It is believed that this increase is due to deterioration of ecological situation, distribution of viral hepatites (A, B, C, and D), as well as toxic and drug-induced lesions of the liver [8,13,14]. In the opinion of Academician L.A. Piruzyan, different individual sensitivity of humans to various environmental factors requires designing the system of biochemical metabolic certification that will allow individual prophylaxis and therapy of numerous dangerous diseases to be performed [3,7]. Currently, the susceptibility of humans to various diseases is thought to be related to individual activity of xenobiotic detoxication [1-3, 7, 11].…”