PPAR-Gamma Agonist Rosiglitazone Attenuates the Inflammation Caused by Carrageenan in the Mouse Model of Pleurisy

Abstract

The aim of this study was to investigate the anti-inflammatory efficacy of rosiglitazone (ROSI) in a pleurisy model of carrageenan-induced inflammation. Efficacy was monitored in the mouse pleural cavity by evaluating leukocyte migration, exudate concentration, and myeloperoxidase (MPO) and adenosine deaminase (ADA) activities concomitantly with nitrate/nitrite (NOx), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-17A (IL-17A), and vascular endothelial growth factor-alpha (VEGF-α) levels 4 and 48 h after pleurisy induction. In both phases (4 and 48 h) of pleurisy, ROSI inhibited all the inflammation parameters that were tested (p<0.05). These results provide evidence that ROSI was efficacious in inhibiting pro-inflammatory mediators. These anti-inflammatory effects are assumed to mainly result from the inhibition of products released from activated leukocytes, such as MPO, ADA, NOx, TNF-α, IL-1β, IL-17A, and VEGF-α.

Contribution ofα,β-Amyrenone to the Anti-Inflammatory and Antihypersensitivity Effects ofAleurites moluccana(L.) Willd.

“…The experiments were carried out according to the methodology described by Da Silva Buss et al [15]. To evaluate the exudation into the pleural cavity, animals received an Evans blue dye solution (25 mg/kg, 0.2 mL, i.v.)…”

Rosiglitazone attenuates the severity of hyperlipidemic severe acute pancreatitis in rats

“…Rosiglitazone has shown to have protective effects against hyperoxia-induced lung injury (24). Therefore, the anti-inflammatory effects of TZDs may be a general characteristic of PPAR-γ activation, as this phenomenon has been indicated in certain models of critical diseases (25,26). The PPAR-γ natural agonist 15d-prostaglandin J2 was shown to exhibit protective effects in the brain against ischemia-reperfusion injury (27) and to reduce the development of inflammation in mice with acute lung injury induced by lipopolysaccharides (28).…”

Tetrazoles as PPARγ ligands: A structural and computational investigation

“…Several lines of evidence suggest that the anti-inflammatory effects of PPAR activation may be useful for neuroprotection [17,18], management of endothelial function [19,20] and colitis [21]. Besides its action on TNF- levels, the carrageenan mouse model suggests that PPAR activation also regulates the level of myeloperoxidase, adenosine deaminase, IL-1, IL-17, and VEGF- [22].…”