PPARγ agonist-induced alterations in Δ6-desaturase and stearoyl-CoA desaturase 1: Role of MEK/ERK1/2 pathway

Saliani, Negar; Darabi, Masoud; Yousefi, Bahman; Baradaran, Behzad; Khaniani, Mahmoud Shekari; Darabi, Maryam; Shaaker, Maghsod; Mehdizadeh, Amir; Naji, Tahereh; Hashemi, Mehrdad

doi:10.4254/wjh.v5.i4.220

Cited by 24 publications

(14 citation statements)

References 36 publications

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“…Among the several investigated hepatic mitogenic pathways, only Wnt/β‐catenin pathway was directly associated with liver regeneration after the APAP treatment (Yousefi, Darabi, Baradaran, Shekari Khaniani, & Rahbani, ). In addition, activation of Wnt/β‐catenin pathway stimulated proliferation of hepatocytes (Gougelet & Colnot, ; Wang, Zhao, Fish, Logan, & Nusse, ), and the more quiescent liver progenitors (Yang et al, ), which often contributes toward liver regeneration (Saliani et al, ). Pre‐treatment with a Wnt/β‐catenin agonist activates the inhibited hepatocyte proliferation in the small‐for‐size rat liver graft model (Ma et al, ).…”

Section: Wnt/β‐catenin Signaling In Regenerative Medicinementioning

confidence: 99%

The roles of Wnt/β‐catenin pathway in tissue development and regenerative medicine

Majidinia

Akhondian²,

Jahanban‐Esfahlani³

et al. 2018

Journal Cellular Physiology

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107

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Regenerative medicine is a translational field which combines tissue engineering and molecular biology to construct spare organs or help injured or defective tissues to regenerate or restore their normal functions. This is particularly important with specific organs such as heart, central nervous system, retina, or limbs which possess very limited regenerative capacity. As such, regenerative medicine has received peculiar attention in the last decade. In this regard, Wnt/β-catenin signaling pathway has been subject to intensive research, since it plays many essential roles in the regulation of the progenitor cell fate, developmental decisions, proliferation during embryonic development, and adult tissue homeostasis. In this paper, we will briefly introduce Wnt/β-catenin signaling pathway and discuss how it integrally contributes to both stem and cancer stem cell maintenance. Finally, we summarize the current understanding of the role of Wnt/β-catenin signaling in the development and regeneration of heart, lung, liver, bone, and cartilage.

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Section: Wnt/β‐catenin Signaling In Regenerative Medicinementioning

confidence: 99%

The roles of Wnt/β‐catenin pathway in tissue development and regenerative medicine

Majidinia

Akhondian²,

Jahanban‐Esfahlani³

et al. 2018

Journal Cellular Physiology

Self Cite

107

View full text Add to dashboard Cite

show abstract

“…As a major cell type in tumor stroma, CAFs have an undeniable importance in progression, metastasis, and MDR of various cancer types including breast cancer . In particular, CAFs usually express several growth factors, for example, hepatocytes growth factor (HGF) and WNT16B, as well as chemokine (C‐C) ligand 2 (CCL2) and chemokine (C‐X‐C) ligand 12 (CXCL12), plus a number of other ECM‐related proteins . CAF‐expressed proteins are main links of CAFs with MDR (Figure ).…”

Section: Resistance To Therapies Mediated By Breast Tumor Stromamentioning

confidence: 99%

Breast tumor stroma: A driving force in the development of resistance to therapies

Majidinia

Yousefi

2017

Chem Biol Drug Des

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Breast cancer is the most common cancer and the second leading cause of cancer-related death in women worldwide. In spite of huge advancements in early detection and ever-increasing knowledge of breast cancer biology, approximately 30% of patients with early-stage breast cancer experience disease recurrence. Most patients are chemosensitive and cancer free immediately after the treatment. About 50% to 70% of breast cancer patients, however, will relapse within 1 year. Such a relapse is usually concomitant with adenocarcinoma cells acquiring a chemoresistant phenotype. Both de novo and acquired chemoresistance are poorly understood and present a major burden in the treatment of breast cancer. Although, previously, chemoresistance was largely linked to genetic alterations within the cancer cells, recent investigations are indicating that chemoresistance can also be associated with the tumor microenvironment. Nowadays, it is widely believed that tumor microenvironment is a key player in tumor progression and response to treatment. In this study, we will review the interactions of breast tumor cells with their microenvironment, present the latest research on the resistance mediated by the stromal component in breast cancer, and discuss the potential therapeutic strategies that can be exploited to treat breast cancers by targeting tumor microenvironment.

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“…[10][11][12] PPARs form heterodimers with retinoid X receptors (RXRs) and bind to PPAR response elements (PPREs) located in the promoter of target genes to regulate transcription. 13,14 PPARγ agonists have also been demonstrated to have beneficial effects in different types of tumor cells including gastric, 15 colon, 16 leukemia, 17 hepatocellular carcinoma, 18 pancreas, 19 breast, 20 and prostate 21 cancers. PPARγ agonists have been reported to activate phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein expression.…”

Section: Introductionmentioning

confidence: 99%

Balaglitazone reverses P-glycoprotein-mediated multidrug resistance via upregulation of PTEN in a PPARγ-dependent manner in leukemia cells

et al. 2017

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Multidrug resistance in tumor cells is still a big challenge in cancer treatment. Therefore, identification ofsafe and effective multidrug resistance-reversing compounds with minimal side effects is an important approach in cancer treatment. Here, we investigated the role and potential mechanisms of peroxisome proliferator-activated receptor γ in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells. The effect of doxorubicin on cell viability following treatment with balaglitazone, a peroxisome proliferator-activated receptor γ agonist, was evaluated using trypan blue and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Rhodamine123 assay was used to determine the activity of two common drug efflux membrane transporters P-glycoprotein and multidrug resistance protein-1. P-glycoprotein, multidrug resistance protein-1, and phosphatase and tensin homolog deleted on chromosome 10 messenger RNA/protein expression levels were measured by quantitative reverse transcription polymerase chain reaction and western blot analyses. Annexin V/fluorescein isothiocyanate assay was also employed to investigate apoptosis. We showed that balaglitazone considerably enhanced the cytotoxicity of doxorubicin. Balaglitazone also significantly downregulated P-glycoprotein expression and activity in K562/DOX cells and reduced multidrug resistance through elevation of intracellular doxorubicin in cells. Furthermore, upon balaglitazone treatment, phosphatase and tensin homolog deleted on chromosome 10 expression could be restored in K562/DOX cells in a peroxisome proliferatoractivated receptor γ-dependent manner. We concluded that peroxisome proliferator-activated receptor γ agonist, balaglitazone, could reverse multidrug resistance by inducing phosphatase and tensin homolog deleted on chromosome 10 and peroxisome proliferator-activated receptor/ phosphatase and tensin homolog deleted on chromosome 10 signaling pathway. These findings suggest that targeting peroxisome proliferator-activated receptor γ might serve as an effective approach for circumventing multidrug resistance in chemotherapy of cancerous patients.

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PPARγ agonist-induced alterations in Δ6-desaturase and stearoyl-CoA desaturase 1: Role of MEK/ERK1/2 pathway

Abstract: PPARγ and ERK1/2 signaling pathway affect differentially and may have inhibitory crosstalk effects on the genes expression of ∆6D and SCD1, and subsequently on their enzymatic activities.

Cited by 24 publications

References 36 publications

The roles of Wnt/β‐catenin pathway in tissue development and regenerative medicine

The roles of Wnt/β‐catenin pathway in tissue development and regenerative medicine

Breast tumor stroma: A driving force in the development of resistance to therapies

Balaglitazone reverses P-glycoprotein-mediated multidrug resistance via upregulation of PTEN in a PPARγ-dependent manner in leukemia cells

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