PPO.58 Outcome of Pregnancy with Low PAPP-A

Abstract

10/34(29%) women with pre-existing psychiatric illness had SVD compared to 74/161(46%) in the control group [RR = 0.89, 95% CI = 0.78-1.01, p = N/S]. 13/34(38%) required caesarean section compared to 42/161(26%) [RR = 1.1, 95% CI = 0.95-1.31, p = N/S]. 11/34(32%) required operative vaginal delivery compared to 45/161(28%) [RR = 1.04, 95% CI = 0.89-1.21, p = N/S].For women with psychiatric illness, median gestation at delivery was 39 weeks (Range = 24-41 weeks). 13/34(38%) had induction of labour (IOL) compared to 32/161(20%) [RR = 1.21, 95% CI = 1.0-1.47, p = 0.03]. The median birth weight for women with psychiatric illness was 3115g (Range = 910-4320 g).There were no differences in the rates of pre-term birth, stillbirth, perineal trauma and post-partum haemorrhage, and no differences in perinatal morbidity. Conclusions Almost 1 in 5 women attending for ante-natal care has a history of psychiatric illness. There was a high rate of obstetric interventions, but other than IOL, none reached statistical significance. It is reassuring to note that women with preexisting psychiatric morbidity do not appear to be at risk of adverse perinatal outcome.