PPR virus threatens wildlife conservation

Fernández-Aguilar, Xavier; Fine, Amanda E.; Pruvot, Mathieu; Njeumi, Félix; Walzer, Chris; Kock, Richard; Shiilegdamba, Enkhtuvshin

doi:10.1126/science.aav4096

Cited by 39 publications

(47 citation statements)

References 4 publications

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“…The disease is caused by peste-des-petits-ruminants virus (PPRV), classified as a Small ruminant morbillivirus (Amarasinghe et al 2018). Recently, PPR has caused devastating outbreaks among the endangered Mongolian saiga (Saiga tatarica mongolica) and is considered a threat to wildlife conservation (Aguilar et al 2018). Presence of PPR has been recognised in Pakistan since 1991 (Abubakar and Munir 2014), and the first outbreak of PPR in Tajikistan was reported in 2004 (Kwiatek et al 2007).…”

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confidence: 99%

“…Variation in susceptibility to PPRV infection between species is probably due to host receptor affinity (Kumar et al 2014), as suggested by the fact that Vero cells expressing the goat signalling lymphocyte activation molecule (SLAM) receptor are more prone to PPRV infection than cells expressing the bovine SLAM receptor (Adombi et al 2011). Circulation of PPRV in domestic animals intermingling with wildlife has been shown to be a threat to endangered wildlife species (Aziz-ul-Rahman et al 2018), such as the Mongolian saiga (Aguilar et al 2018). Semidomestic yaks are intermingling with both domestic and wild animals, depending on season, and might therefore be a potential source for such spill-over effects from domestic animals to wildlife.…”

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confidence: 99%

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Detection of antibodies to peste-des-petits-ruminants virus in the semi-domesticated yak

Abubakar¹,

Sattorov

Manzoor³

et al. 2019

Eur J Wildl Res

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Peste des petits ruminants (PPR) is a highly contagious and acute viral disease of small ruminants. Occasionally, PPR can affect wildlife with devastating results, such as the recent outbreaks in Mongolian saiga. The yak (Bos grunniens and Bos mutus) is a large ruminant found throughout the Himalayan region of south Central Asia, the Tibetan Plateau and as far north as Mongolia and Russia. In Pakistan, yaks are confined to the high plateau of the Northern Areas, from Gilgit to the valley of Ladakh. In Tajikistan, yaks are present in districts in the north, east and southeast of the country. Commonly, yak intermingle with domestic animals during winter when mountainous summer pastures are covered with snow, and with wildlife during summer pastures. PPR is considered endemic in sheep and goats in Pakistan and Tajikistan. In this study, we investigated the potential presence of antibodies to peste-des-petits-ruminants virus (PPRV) in yak populations using ELISA. A total of 250 (Pakistan) and 85 (Tajikistan) serum samples of healthy yaks were collected. None of the Tajik yaks were seropositive (95% confidence interval (CI) 0.0-4.2%), while 23 of 250 (9.2%; 95% CI 5.9-13.5%) yaks sampled in Pakistan were found positive. Whether PPRV is continuously circulating among yaks or seroconversion reflects spill-over from outbreaks of PPR in domestic animals remains unknown. Due to the herding practices, yak might transmit PPR from domestic to wild ruminants. Differences in contacts between yaks and domestic animals in Pakistan and Tajikistan, or the low sample size, could explain that no Tajik yaks were seropositive.

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confidence: 99%

Detection of antibodies to peste-des-petits-ruminants virus in the semi-domesticated yak

Abubakar¹,

Sattorov

Manzoor³

et al. 2019

Eur J Wildl Res

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“…A recent outbreak of PPR in dorcas gazelle in Dinder National Park, Sudan is the first verifiable report of disease in free-ranging antelope in sub-Saharan Africa, but more pathological and epidemiological data are needed to confirm the laboratory findings [32]. A shift in PPR epidemiology as wildlife becomes increasingly stressed by rising human and livestock numbers and associated loss of forage and disturbance, could be a concerning development for wildlife economies in East Africa that need to be vigilant [4,32]. This is certainly the characteristic of the Asian ecosystems where PPR is readily expressed in wildlife.…”

Section: Discussionmentioning

confidence: 99%

“…The disease peste des petits ruminants (PPR), is one of the most important and devastating infectious diseases in domestic small ruminants across more than 70 countries, causing economic losses of 1.45 to 2.1 billion United States Dollar (USD) each year, potentially threatening 80% of the worldwide small livestock and the livelihoods of 900 million poor farmers [2,3]. PPR is also a significant disease and the cause of mortality in captive and wild artiodactyls in Asia and the Middle East, and an emerging threat to wildlife conservation [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Peste des Petits Ruminants at the Wildlife–Livestock Interface in the Northern Albertine Rift and Nile Basin, East Africa

Fernández-Aguilar

Mahapatra

Begovoeva

et al. 2020

Viruses

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“…In December 2016, the disease was diagnosed in several wildlife populations in eastern Mongolia, e.g. saiga antelope (Saiga tatarica mongolica), ibex (Capra sibirica) and goitre gazelle (Gazella subgutturosa), with more than 5000 deaths (4). It is important to ensure that the currently commercially available tests for PPRV serology are validated in serum samples from these wild animal species.…”

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Eradication of peste des petits ruminants: Application of new research to guide and facilitate the global elimination of the disease

Niedbalski¹

2020

Medycyna Weterynaryjna

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Peste des petits ruminants (PPR) is a highly contagious viral disease of domestic and wild small ruminants caused by the peste des petits ruminants virus (PPRV), which belongs to the genus Morbilivirus in the family Paramyxoviridae. The PPRV causes disease in goats and sheep, as well as in wild ruminants, such as gazelle, deer, antelope, Nubian ibex, gemsbok and others. PPR was first recorded in early 1942 in Ivory Coast, West Africa, and spread to around 70 countries in Africa, the Middle East and Asia – regions that are home to over 80% of the world’s sheep and goats. Until 2018, PPR had never been detected in Europe. On 24th June 2018, however, the Bulgarian authorities reported cases of PPR in sheep in the village of Voden, Bolyarovo municipality of Yambol region, on the border with the Thrace region of Turkey. It was the first occurrence of PPR in Bulgaria and in the European Union (EU). The control and eventual eradication of PPR is now one of the top priorities for the Food and Agriculture Organization (FAO) and the World Organization for Animal Health (OIE). In 2015, the international community agreed on a global strategy for PPR eradication, setting 2030 as a target date for elimination of the disease. The aim of this paper was to highlight future research that could be performed to guide and facilitate the PPR eradication programme. Such research includes studies on PPR transmission and epidemiology, as well as the development and application of new-generation PPR vaccines capable of differentiating infected from vaccinated animals (DIVA). Moreover, there is a need for research to improve and adapt existing diagnostic techniques as well as to develop novel PPRV recognition methods, such as a lateral flow device for in-field use, that accelerate decisions about the implementation of control measures.

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PPR virus threatens wildlife conservation

Cited by 39 publications

References 4 publications

Detection of antibodies to peste-des-petits-ruminants virus in the semi-domesticated yak

Detection of antibodies to peste-des-petits-ruminants virus in the semi-domesticated yak

Peste des Petits Ruminants at the Wildlife–Livestock Interface in the Northern Albertine Rift and Nile Basin, East Africa

Eradication of peste des petits ruminants: Application of new research to guide and facilitate the global elimination of the disease

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