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Sapronov, N. S.; Khnychenko, L. K.; Polevshchikov, A. V.

doi:10.1023/a:1017587727533

Cited by 12 publications

(5 citation statements)

References 4 publications

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“…The increased excretory function of adrenal glands in rats chronically exposed to energy drinks may be partially related also to taurine—according to Sapronov et al, taurine derivatives increase cortisol secretion. [ 27 ]. It has lately been reported that taurine itself causes increase in corticosterone levels in rats [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Decrease in Lipid Droplets in Adrenal Cortex of Male Wistar Rats after Chronic Exposure to Energy Drinks

et al. 2018

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Background and objectives: Energy drinks are popular non-alcoholic beverages. They are consumed in large amounts, mainly by active, young people. Although they are easily accessible and marketed as safe, numerous cases of adverse effects have been published, including cardiac arrest, arrythmias, acute hepatitis, and renal failure. The aim of the current study is the assessment of energy drink influence on the histological structure of adrenal cortex in rats. Material and Methods: 15 male young Wistar rats were equally divided into three groups: control (C), experimental (E) and reversibility control (RC). C group received water and standard rodent food ad libitum while both E and RC groups had additionally unlimited access to energy drinks. C and E groups were decapitated after 8 weeks and RC was given another 8 weeks without energy drinks. Adrenal glands were embedded in paraffin blocks and 5 μm slides were prepared and stained according to standard H&E and Masson’s trichrome protocols. Additionally, immunohistochemical stainings against Ki-67, p53, CTGF and caspase-3 were prepared. Results: Decreased vacuolization and numerous pyknotic nuclei were noted in E and RC groups. Overexpression of caspase-3 was noted both subcapsular in zona glomerulosa and along sinusoids in zona fasciculata. Increased collagen deposition in zona glomerulosa and zona fasciculata of E and RC was observed. Insular and irregular overexpression of CTGF was noted. The overall picture of CTGF expression matched the Masson’s trichrome. No significant difference was observed in Ki-67 expression. Conclusions: The results of the current study suggest that the stimulation is so intense that it causes significant damage to adrenal cortical cells, resulting in their apoptosis. It seems, however, that the observed effects are at least partially reversible.

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Section: Discussionmentioning

confidence: 99%

Decrease in Lipid Droplets in Adrenal Cortex of Male Wistar Rats after Chronic Exposure to Energy Drinks

et al. 2018

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“…In particular, taurine-deficient cats presented significant leukopenia, decreased respiratory burst in neutrophils, and depletion of cells from B cell areas in lymph nodes and splenic follicle centers ( 32 ). Apart from leukopenia, taurine deficiency proved to cause functional defects of the neutrophils and decreased phagocytosis of microorganisms such as Staphylococcus epidermis ( 5 , 33 ). Conversely, taurine was reported to mediate its ameliorative effect on age-related decline in the proliferative ability of lymphocytes through increasing calcium levels.…”

Section: The Role Of Taurine In Inflammationmentioning

confidence: 99%

“…In particular, the effect of taurine was more potent on T-cells, that were more susceptible to age-related decline in proliferation than B lymphocytes ( 32 ). The effect of taurine on lymphocyte function was substantiated through its chaperoning role concerning MHC class II antigen expression ( 33 ). The aforementioned data were evaluated given that T-cell proliferation is mediated independently of the age-related alteration in taurine transport ( 34 ).…”

Section: The Role Of Taurine In Inflammationmentioning

confidence: 99%

Role of taurine, its haloamines and its lncRNA TUG1 in both inflammation and cancer progression. On the road to therapeutics? (Review)

Baliou

Kyriakopoulos²,

Spandidos

et al. 2020

Int J Oncol

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For one century, taurine is considered as an end product of sulfur metabolism. In this review, we discuss the beneficial effect of taurine, its haloamines and taurine upregulated gene 1 (TUG1) long non-coding RNA (lncRNA) in both cancer and inflammation. We outline how taurine or its haloamines (N-Bromotaurine or N-Chlorotaurine) can induce robust and efficient responses against inflammatory diseases, providing insight into their molecular mechanisms. We also provide information about the use of taurine as a therapeutic approach to cancer. Taurine can be combined with other chemotherapeutic drugs, not only mediating durable responses in various malignancies, but also circumventing the limitations met from chemotherapeutic drugs, thus improving the therapeutic outcome. Interestingly, the lncRNA TUG1 is regarded as a promising therapeutic approach, which can overcome acquired resistance of cancer cells to selected strategies. In this regard, we can translate basic knowledge about taurine and its TUG1 lncRNA into potential therapeutic options directed against specific oncogenic signaling targets, thereby bridging the gap between bench and bedside. Contents 1. The role of taurine in inflammation 2. Formation of taurine haloamines 3. Anti-microbial properties of taurine haloamines 4. Anti-inflammatory and anti-oxidant properties of taurine haloamines 5. Therapeutic perspectives and clinical studies 6. Significance of lncRNA TUG1 lncRNA in cancer 7. The association of lncRNA TUG1 and chemoresistance 8. The role of taurine or lncRNA TUG1 as a prognostic marker 9. Conclusions

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“…muscles) and act as nutrients for cells of the immune system and also for the synthesis of taurine, glutathione and acute phase protein (APP) [163]. Taurine is found in inflammatory cells e.g.…”

Section: (N) Modulation Of the Immune Systemmentioning

confidence: 99%

Taurine Analogues; A New Class of Therapeutics: Retrospect and Prospects

Gupta

Win

Bittner

2005

CMC

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Taurine was discovered more than two hundred years ago from animal sources. It is distributed in both mammals and non-mammals and its content is high in several tissues. For more than a century-and-a-half, taurine was regarded just as an end product of sulfur metabolism. Recently, taurine has been rediscovered and its beneficial effects in processes like epilepsy, hypertension, congestive heart failure and diabetes have been well-documented. It was patented and found some clinical utility, but being an amino acid, therapeutic use confronts limitations like restricted permeability and more. This necessitates the development of pro-drugs (analogues) mainly derivatives of taurine. A large number of taurine derivatives have been reported in the literature with partial to marked activity. Taurine derivatives like taltrimide, acamprosate and tauromustine, are already in the market as anti-convulsant, anti-alcoholic and anti-cancer agents. Many other analogues are effective in experimental models. The in depth analysis of these analogues and their biological actions can provide certain clues for further consideration. In the present review, attempts have been made to provide synopsis, synthesis and symbiosis of chemical and biological actions, which may provide future guidance and facilitate further research in this area. The successful journey of these analogues to clinical utility is a healthy and happy sign and an index of bright future, and we hope that this review will provide enough input to ignite the minds.

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Cited by 12 publications

References 4 publications

Decrease in Lipid Droplets in Adrenal Cortex of Male Wistar Rats after Chronic Exposure to Energy Drinks

Decrease in Lipid Droplets in Adrenal Cortex of Male Wistar Rats after Chronic Exposure to Energy Drinks

Role of taurine, its haloamines and its lncRNA TUG1 in both inflammation and cancer progression. On the road to therapeutics? (Review)

Taurine Analogues; A New Class of Therapeutics: Retrospect and Prospects

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