PR_b-targeted delivery of tumor necrosis factor-α by polymersomes for the treatment of prostate cancer

Demirgöz, Döne; Pangburn, Todd O.; Davis, K.; Lee, Sangwoo; Bates, Frank S.; Kokkoli, Efrosini

doi:10.1039/b814217c

Cited by 74 publications

(58 citation statements)

References 81 publications

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“…Besides, other properties, such as biodegradability, biocompatibility, cell specific adhesion, and stimulus response, are always expected to meet a series of requirements for their clinical applications. [4][5][6] Therefore it is a significant task to exploit ideal copolymers for vesicles.…”

Section: Introductionmentioning

confidence: 99%

Novel Polymeric Vesicles with pH‐Induced Deformation Character for Advanced Drug Delivery

Cheng

Yao

Qiu

2010

Macromolecular Bioscience

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pH-responsive amphiphilic graft macromolecules consisting of a polyphosphazene backbone, hydrophilic PEG branches and pH-sensitive DPA were successfully synthesized and characterized. The copolymer can self-assemble into vesicles in an aqueous solution with unique inner structure and homogeneously encapsulate both lipophilic and hydrophilic molecules. The pH-dependent structure change of vesicles was also observed by DLS and TEM. Dox-loaded vesicles exhibit a sharp pH-responsive drug release profile and dramatically enhance the cytotoxicity of Dox against Dox-resistant MCF-7/adr cells. These results suggest such vesicles based on pH-responsive polyphosphazene hold great potential for specific drug therapy.

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Section: Introductionmentioning

confidence: 99%

Novel Polymeric Vesicles with pH‐Induced Deformation Character for Advanced Drug Delivery

Cheng

Yao

Qiu

2010

Macromolecular Bioscience

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“…The biocompatibility of PBD-b-PEG makes this block copolymer a popular choice for cell targeting studies and potential biomedical applications [71]. Kokkoli and co-workers prepared PBD-b-PEG-based polymersomes that were decorated with a targeting peptide that mimics the cell adhesion site in fibronectin [72]. The peptide was conjugated at its N-terminus with a block copolymer bearing an N-hydroxysuccinimide end group.…”

Section: Formation Of Polymersomes From End-functionalized Block Copomentioning

confidence: 99%

Functionalization of Block Copolymer Vesicle Surfaces

et al. 2011

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Abstract:In dilute aqueous solutions certain amphiphilic block copolymers self-assemble into vesicles that enclose a small pool of water with a membrane. Such polymersomes have promising applications ranging from targeted drug-delivery devices, to biosensors, and nanoreactors. Interactions between block copolymer membranes and their surroundings are important factors that determine their potential biomedical applications. Such interactions are influenced predominantly by the membrane surface. We review methods to functionalize block copolymer vesicle surfaces by chemical means with ligands such as antibodies, adhesion moieties, enzymes, carbohydrates and fluorophores. Furthermore, surface-functionalization can be achieved by self-assembly of polymers that carry ligands at their chain ends or in their hydrophilic blocks. While this review focuses on the strategies to functionalize vesicle surfaces, the applications realized by, and envisioned for, such functional polymersomes are also highlighted.

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“…Increased cytotoxic potential of delivered TNF-α was seen with targeted polymersomes than non-targeted polymersomes. 116 …”

mentioning

confidence: 99%

Polymeric nanoparticles for targeted treatment in oncology: current insights

Prabhu¹,

Patravale²,

Joshi³

2015

IJN

176

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Chemotherapy, a major strategy for cancer treatment, lacks the specificity to localize the cancer therapeutics in the tumor site, thereby affecting normal healthy tissues and advocating toxic adverse effects. Nanotechnological intervention has greatly revolutionized the therapy of cancer by surmounting the current limitations in conventional chemotherapy, which include undesirable biodistribution, cancer cell drug resistance, and severe systemic side effects. Nanoparticles (NPs) achieve preferential accumulation in the tumor site by virtue of their passive and ligand-based targeting mechanisms. Polymer-based nanomedicine, an arena that entails the use of polymeric NPs, polymer micelles, dendrimers, polymersomes, polyplexes, polymer–lipid hybrid systems, and polymer–drug/protein conjugates for improvement in efficacy of cancer therapeutics, has been widely explored. The broad scope for chemically modifying the polymer into desired construct makes it a versatile delivery system. Several polymer-based therapeutic NPs have been approved for clinical use. This review provides an insight into the advances in polymer-based targeted nanocarriers with focus on therapeutic aspects in the field of oncology.

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PR_b-targeted delivery of tumor necrosis factor-α by polymersomes for the treatment of prostate cancer

Cited by 74 publications

References 81 publications

Novel Polymeric Vesicles with pH‐Induced Deformation Character for Advanced Drug Delivery

Novel Polymeric Vesicles with pH‐Induced Deformation Character for Advanced Drug Delivery

Functionalization of Block Copolymer Vesicle Surfaces

Polymeric nanoparticles for targeted treatment in oncology: current insights

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