Practicability of Enhancing Specific Resistance to Staphylococcic Infection

Studies of Staphylococcal Infections. I. Virulence of Staphylococci and Characteristics of Infections in Embryonated Eggs *

“…The effect of the size of the inoculum on the time of death was even more apparent when individual strains were considered. More virulent strains that produced fatality rates of 85% or greater with a small inocula produced 84% of their fatalities in the first 2 Table I. No significant differences were observed among any of the groups, and undiluted overnight cultures of coagulase negative staphylococci were no more lethal than the media in which they were grown.…”

The hemolysins of Staphylococcus aureus.

“…They suggest that determination of gamma antihemolysin titers is useful in diagnosis of the infection and in following the effects of treatment. Mudd (150) and Mudd et al (151) have advocated the use of alpha hemolysin toxoid and Panton-Valentine leucocidin toxoid on the basis of studies in chronically ill and other patients. This view has met with some resistance by other investigators (169).…”

Staphylococcal Septicaemia with Multiple Pyoarthrosis Complicating Rheumatoid Disease

“…Hollander et al (1961) emphasised the importance of recognising suppurative arthritis within 48 hours of the onset in order to minimise the degree of joint destruction. Mudd (1960) mentioned the use of a "toxoid" preparation in the treatment of chronic and recurrent staphylococcal infection of soft tissues and Batch (1962) referred in some detail to the antibiotics which had been given intra-articularly. Other workers had used penicillin, streptomycin or erythromycin in glycerin but he had found that 300 mg erythromycin lactobionate in 6 ml sterile water produced minimal local side effects.…”