Practical applications of digital tomosynthesis of the chest

Galea, Angela; Durran, A.; Adlan, Tarig; Riordan, Richard; Williams, M.

doi:10.1016/j.crad.2013.10.019

Cited by 14 publications

(9 citation statements)

References 8 publications

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“…29,30 In addition to reductions in anatomical noise or composite artefacts, DTS provides greater depth and contrast resolution. 7 Our findings for per-patient data showed that the high diagnostic accuracy of DTS is complemented by greater homogeneity and consistency of results compared with chest radiography.…”

Section: Discussionmentioning

confidence: 75%

“…4,5 Digital tomosynthesis (DTS) is a type of limited-angle tomography that provides continuous coronal images through the area of interest. Because it eliminates overlapping anatomy or composite artefact, DTS facilitates improved lesion detection, depth localization and contrast resolution compared with plain radiography, 6,7 and compared with CT, the cost and radiation dose of DTS are lower. [8][9][10] Therefore, DTS has been recommended by several authors as an alternative to both chest radiography and CT, and the greater diagnostic performance of DTS for detecting pulmonary nodules has been reported.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of digital tomosynthesis and chest radiography for the detection of pulmonary nodules: systematic review and meta-analysis

Kim¹,

Lee²,

Kim³

et al. 2016

The British Journal of Radiology

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Objective: To compare the diagnostic accuracy of digital tomosynthesis (DTS) with that of chest radiography for the detection of pulmonary nodules by meta-analysis. Methods: A systematic literature search was performed to identify relevant original studies from 1 January 1 1976 to 31 August 31 2016. The quality of included studies was assessed by quality assessment of diagnostic accuracy studies-2. Per-patient data were used to calculate the sensitivity and specificity and per-lesion data were used to calculate the detection rate. Summary receiveroperating characteristic curves were drawn for pulmonary nodule detection. Results: 16 studies met the inclusion criteria. 1017 patients on a per-patient basis and 2159 lesions on a per-lesion basis from 16 eligible studies were evaluated. The pooled patient-based sensitivity of DTS was 0.85 [95% confidence interval (CI) 0.83-0.88] and the specificity was 0.95 (0.93-0.96). The pooled sensitivity and specificity of chest radiography were 0.47 (0.44-0.51) and 0.37 (0.34-0.40), respectively. The per-lesion detection rate was 2.90 (95% CI 2.63-3.19). Conclusion: DTS has higher diagnostic accuracy than chest radiography for detection of pulmonary nodules. Chest radiography has low sensitivity but similar specificity, comparable with that of DTS. Advances in knowledge: DTS has higher diagnostic accuracy than chest radiography for the detection of pulmonary nodules.

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Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Comparison of digital tomosynthesis and chest radiography for the detection of pulmonary nodules: systematic review and meta-analysis

Kim¹,

Lee²,

Kim³

et al. 2016

The British Journal of Radiology

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“…Other new outcome measures including a new symptom scale for patients with COPD suitable for daily use;47 a scoring system capable of predicting survival in patients with malignant pleural effusions;48 a lung-transplant specific quality of life score49 and an ultrasonic technique for assessing diaphragmatic thickness and likelihood of successful weaning in patients requiring mechanical ventilation 50. The radiographic pattern of connective tissue disease-associated interstitial lung disease was shown to be heterogeneous by Saketkoo et al 51 Understanding this heterogeneity is a priority before progress can be made with treatment, as is the identification of potential outcome measures.…”

Section: Adult Clinical Year In Reviewmentioning

confidence: 99%

Year in review 2014. Paediatric and adult clinical studies

Bush

Pavord

2015

Thorax

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“…igital chest tomosynthesis (DTS) (1) is a modality in the process of validation for imaging of pulmonary nodules (2)(3)(4)(5). Multiple angular radiographic projections provide section images with reduced disturbance from overlapping anatomy and improved visibility of small structures compared with chest radiography at a lower radiation dose and cost than computed tomography (CT) (1,(5)(6)(7)(8)(9)(10). DTS has been suggested (3-13) as a low-dose alternative to CT for lung cancer screening, metastatic surveillance, follow-up of incidental nodules, and mycobacterial disease, and as a way to examine inconclusive findings on chest radiographic images.…”

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confidence: 99%

Detection and Characterization of Solid Pulmonary Nodules at Digital Chest Tomosynthesis: Data from a Cohort of the Pilot Swedish Cardiopulmonary Bioimage Study

Meltzer¹,

Vikgren²,

Bergman³

et al. 2018

Radiology

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Purpose To investigate the performance of digital tomosynthesis (DTS) for detection and characterization of incidental solid lung nodules. Materials and Methods This prospective study was based on a population study with 1111 randomly selected participants (age range, 50-64 years) who underwent a medical evaluation that included chest computed tomography (CT). Among these, 125 participants with incidental nodules 5 mm or larger were included in this study, which added DTS in conjunction with the follow-up CT and was performed between March 2012 and October 2014. DTS images were assessed by four thoracic radiologists blinded to the true number of nodules in two separate sessions according to the 5-mm (125 participants) and 6-mm (55 participants) cut-off for follow-up of incidental nodules. Pulmonary nodules were directly marked on the images by the readers and graded regarding confidence of presence and recommendation for follow-up. Statistical analyses included jackknife free-response receiver operating characteristic, receiver operating characteristic, and Cohen κ coefficient. Results Overall detection rate ranges of CT-proven nodules 5 mm or larger and 6 mm or larger were, respectively, 49%-58% and 48%-62%. Jackknife free-response receiver operating characteristics figure of merit for detection of CT-proven nodules 5 mm or larger and 6 mm or larger was 0.47 and 0.51, respectively, and area under the receiver operating characteristic curve regarding recommendation for follow-up was 0.62 and 0.65, respectively. Conclusion Routine use of DTS would result in lower detection rates and reduced number of small nodules recommended for follow-up. RSNA, 2018.

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Practical applications of digital tomosynthesis of the chest

Cited by 14 publications

References 8 publications

Comparison of digital tomosynthesis and chest radiography for the detection of pulmonary nodules: systematic review and meta-analysis

Comparison of digital tomosynthesis and chest radiography for the detection of pulmonary nodules: systematic review and meta-analysis

Year in review 2014. Paediatric and adult clinical studies

Detection and Characterization of Solid Pulmonary Nodules at Digital Chest Tomosynthesis: Data from a Cohort of the Pilot Swedish Cardiopulmonary Bioimage Study

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