Practical approach to acute pancreatitis: from diagnosis to the management of complications

Padula, Donatella; Mauro, Aurelio; Maggioni, Paolo; Kurihara, Hayato; Di Sabatino, Antonio; Anderloni, Andrea

doi:10.1007/s11739-024-03666-9

Intern Emerg Med

2024

DOI: 10.1007/s11739-024-03666-9

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Practical approach to acute pancreatitis: from diagnosis to the management of complications

Donatella Padula,

Aurelio Mauro,

Paolo Maggioni

et al.

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Cited by 3 publications

References 89 publications

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S100A9 Inhibition Mitigates Acute Pancreatitis by Suppressing RAGE Expression and Subsequently Ameliorating Inflammation

Shou,

Sun,

Zhang

et al. 2024

Inflammation

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S100A9 Inhibition Mitigates Acute Pancreatitis by Suppressing RAGE Expression and Subsequently Ameliorating Inflammation

Shou,

Sun,

Zhang

et al. 2024

Inflammation

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Comparative study of gut microbiota and metabolite variations between severe and mild acute pancreatitis patients at different stages

Wang,

Chen,

Han

et al. 2025

Microbial Pathogenesis

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Understanding the Role of NLRP3 Inflammasome in Acute Pancreatitis

Papantoniou,

Aggeletopoulou,

Michailides

et al. 2024

Biology

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Acute pancreatitis (AP) remains a serious clinical condition, with current treatment options being largely supportive. The discovery of inflammasomes, particularly the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, has significantly advanced our knowledge regarding many inflammatory diseases’ pathogenesis, including AP. The NLRP3 inflammasome is central in mediating the inflammatory process in AP through its diverse activation mechanisms and its involvement in multiple signal transduction pathways. This has made NLRP3 an appealing target for novel therapeutic strategies aimed at modulating inflammation in AP. Despite the growing interest in NLRP3 as a therapeutic target, there remains a notable gap in clinical research, with few clinical trials exploring the efficacy of NLRP3 inhibitors in AP. Results of several preclinical studies and animal models are promising and suggest that the use of NLRP3 inhibitors could result in reduced inflammation and improved patient outcomes in AP. Further research is urgently needed to assess their potential benefits, safety, and applicability in human patients and address the underlying inflammatory processes driving AP.

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Practical approach to acute pancreatitis: from diagnosis to the management of complications

Cited by 3 publications

References 89 publications

S100A9 Inhibition Mitigates Acute Pancreatitis by Suppressing RAGE Expression and Subsequently Ameliorating Inflammation

S100A9 Inhibition Mitigates Acute Pancreatitis by Suppressing RAGE Expression and Subsequently Ameliorating Inflammation

Comparative study of gut microbiota and metabolite variations between severe and mild acute pancreatitis patients at different stages

Understanding the Role of NLRP3 Inflammasome in Acute Pancreatitis

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