Practical approaches on the long-acting injections

Kim, Yu Chul; Min, Kyung Up; Jang, Dong‐Jin; Ahn, Tae Young; Min, Jae; Yu, Byeong Eun; Cho, Kwan Hyung

doi:10.1007/s40005-019-00452-0

Cited by 35 publications

(13 citation statements)

References 72 publications

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“…Several experiments have tried to provide longer-lasting analgesia following a single dose, including modifying molecular structures, adding adjuvants such as vasoconstrictors, and incorporating biodegradable polymeric microparticles and/or nanomembrane, conventional and/or in situ hydrogels, or liposomes. [3][4][5][6][7][8][9][10][11][12][13] In recent, multivesicular liposomes (MVLs), a one kinds of liposomal systems, have been commercialized. 14 The unique carrier system (Exparel ® , Pacira Pharmaceuticals Inc. New Jersey) encapsulates the analgesic agent, which then allows a sustained release for up to 72 h after a single injection, significantly decreasing postoperative opioid consumption.…”

Section: Introductionmentioning

confidence: 99%

“…Despite a longer duration of action than ester‐type local anesthetics, BUP usually lasts less than 8 h in adults following single injection, because of their short half‐life, which is insufficient for clinical application, especially for long‐term surgery or postoperative analgesia. Several experiments have tried to provide longer‐lasting analgesia following a single dose, including modifying molecular structures, adding adjuvants such as vasoconstrictors, and incorporating biodegradable polymeric microparticles and/or nanomembrane, conventional and/or in situ hydrogels, or liposomes 3–13 . In recent, multivesicular liposomes (MVLs), a one kinds of liposomal systems, have been commercialized 14 .…”

Section: Introductionmentioning

confidence: 99%

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Nanocomplex System of Bupivacaine with Dextran Sulfate for Parenteral Prolonged Delivery

Kim

Park

Kang

2020

Bulletin Korean Chem Soc

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An electrostatic complex system of bupivacaine (BUP), an amide-type analgesic agent, with an oppositely charged polymer was designed for parenteral sustained delivery. The complex was prepared by admixing the drug (0.25-1.0% w/v) with different anionic polymers (dextran sulfate, carboxymethylcellulose, or carboxymethyl dextran, 1.0-5.0% w/v), and then adding calcium ion (0-1.0% w/v) as the noncovalent crosslinking agent. Negatively charged complexes ranging from 10 to 2000 nm were formed after the positively charged BUP molecules amalgamated with the polymers after gentle agitation. Drug released from the complex was markedly sustained either by increasing the polymer to drug ratio, or by increasing the calcium ion content. The optimized nanocomplex consisted of the drug, dextran sulfate, and calcium ion at the ratio of 1:20:20 w/w/w, which supplied a sustained release profile over 7 days. Therefore, novel nanocomplex is expected to be an effective tool to provide a sustained release of the analgesic agent.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanocomplex System of Bupivacaine with Dextran Sulfate for Parenteral Prolonged Delivery

Kim

Park

Kang

2020

Bulletin Korean Chem Soc

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“…1 However, traditional direct drug administration to patients is limited due to poor solubility, undesirable side effects, limited cancer targeting, poor pharmacokinetics and biodistribution, and rapid metabolization and excretion. 2,3 Despite the wide arsenal of drugs used in medicine, one of the most important problems remains their targeted delivery in order to increase the effectiveness of treatment. Drug delivery is the most promising approach to solving the problem of the safe transportation of a drug through the body to achieve its target.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in metallopolymer-based drug delivery systems

et al. 2019

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“…LAI is a dosage form that lasts for a prolonged period of time with a single administration and is attracting attention because it solves the problem of poor patient compliance and maintains drug concentration for a long time. 1,2 An in situ forming implant (ISFI) is an LAI drug delivery system that utilizes the sol-gel conversion process.…”

Section: Introductionmentioning

confidence: 99%

Double-Controlled Release of Poorly Water-Soluble Paliperidone Palmitate from Self-Assembled Albumin-Oleic Acid Nanoparticles in PLGA in situ Forming Implant

Ngo

Jin

et al. 2021

IJN

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Purpose: To investigate the effects of solvents on the formation of self-assembled nanonization of albumin-oleic acid conjugates (AOCs) using a solvent exchange mechanism for the construction of in situ forming implants (ISFI). Methods: A poorly water-soluble drug, paliperidone palmitate (PPP), was chosen as the model drug. AOC was synthesized with the 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) reaction. Dichloromethane, tetrahydrofuran, ethanol, N-methyl-2-pyrrolidone, dimethyl sulfoxide, and deionized water were selected to investigate the formation of selfassembled AOC nanoparticles (AONs). The volume ratios of organic solvents against water could determine the miscibility, injectability, and in situ nanonizing capability without aggregation. Results: As the polarity of the organic solvents increased, the AONs exhibited a spherical shape, and the larger the volume of the solvent, the smaller the size of the AONs. To use AOC in ISFI for controlled release of PPP, poly(d,l-lactide-co-glycolide) (PLGA) was combined with the AOC in 2 mL of N-methyl-2-pyrrolidone and water solution (1.8/0.2 ratio). The release rates of all formulations exhibited similar curve patterns overall but were more controlled in decreasing order as follows: AOC, PLGA, and AOC/PLGA for 14 days. Conclusion:A combined formulation of AOC and PLGA was found to effectively control the initial burst release of the drug.

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Practical approaches on the long-acting injections

Cited by 35 publications

References 72 publications

Nanocomplex System of Bupivacaine with Dextran Sulfate for Parenteral Prolonged Delivery

Nanocomplex System of Bupivacaine with Dextran Sulfate for Parenteral Prolonged Delivery

Recent advances in metallopolymer-based drug delivery systems

Double-Controlled Release of Poorly Water-Soluble Paliperidone Palmitate from Self-Assembled Albumin-Oleic Acid Nanoparticles in PLGA in situ Forming Implant

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