Practical considerations in the use of simultaneous inference for multiple tests

Chandler, Ray Calvin

doi:10.1006/anbe.1995.0069

Cited by 213 publications

(122 citation statements)

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“…Table 1) we presented the raw values of statistical tests; we believe that such approach is useful to comparison with other published investigations on metal interactions in tissues in birds and threshold of toxic metals indicative of acute and chronic exposure or toxicosis, see papers in which the matrices of correlations between concentrations different metals are presented without Bonferroni adjusted P-value; e.g., Wenzel et al (1996), Woshner (2001a, b), Kalisińska et al (2004Kalisińska et al ( , 2007, Mochizuki et al (2008), Larison (2002). The accepted Bonferroni adjusted value agrees with the level of significance recommended for multiple comparisons (Chandler 1995). For remaining tests the significance level was 0.05.…”

Section: Discussionsupporting

confidence: 66%

Metal interactions within and between tissues of nestling rooks Corvus frugilegus

et al. 2012

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Abstract:We analyzed interactions of concentrations of 11 essential and nonessential elements, including toxic metals within and between internal organs (liver, kidney and lung), muscles and bones of nestling rooks Corvus frugilegus with acute cadmium contamination and elevated level of lead. The number of statistically significant (P ≤ 0.05) metal-metal relationships (positive/negative) within particular tissues was the highest in the kidney (7/6), following in the bone (9/2), liver (6/4), lung (5/2) and muscle (5/2). We found eight significant interactions of lead with other metals, and only two of cadmium (only with lead and cobalt, which probably mirrored a greater ability of lead (than in the case of cadmium) to functional and kinetic interaction with other metals, and/or inhibiting effect of lead or cadmium in co-accumulation. Furthermore, a positive relationship between concentration of cadmium and lead in the kidney could hint at the key importance of this organ in detoxification of both toxic metals. Analyses of relationships of individual metals between examined tissues show only positive results in the case of copper (n = 8), following potassium (n = 3), zinc and iron (in both cases n = 2) and a single ones for calcium and magnesium. We concluded that the lack of significant relationships of individual toxic metals (cadmium or lead) between analyzed tissues could result from high levels of these metals, which destroyed detoxifying capacity of kidney, and ultimately enabled a rapid bioaccumulation of these inorganic contaminations in all tissues of examined nestlings. An explanation of concentration of toxic metals in tissues of animals, especially in the case of their high level, require an identification of the actual level of essential elements associated with physiological status of organism.

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Section: Discussionsupporting

confidence: 66%

Metal interactions within and between tissues of nestling rooks Corvus frugilegus

et al. 2012

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“…Family-wise error was corrected for using the Dunn's post hoc test in comparisons between species, but only within each variable. The between-variable family-wise error rate as a result of the many Kruskal-Wallis tests was not corrected for using the standard Bonferroni correction because of its tendency to increase the type II error rate, particularly when sample sizes are small (Chandler, 1995;Garamszegi, 2006). We therefore chose to leave the question of biological significance in the hands of the readers, and limited our discussion to those variables that were highly significantly different between species (P,0.001).…”

Section: Discussionmentioning

confidence: 99%

Baseline Health Parameters and Species Comparisons Among Free-Ranging Atlantic Sharpnose (Rhizoprionodon Terraenovae), Bonnethead (Sphyrna Tiburo), and Spiny Dogfish (Squalus Acanthias) Sharks in Georgia, Florida, and Washington, Usa

Haman

Norton

Thomas

et al. 2012

Journal of Wildlife Diseases

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ABSTRACT:Sharks are of commercial, research, conservation, and exhibition importance but we know little regarding health parameters and population status for many species. Here we present health indicators and species comparisons for adults of three common wild-caught species: 30 Atlantic sharpnose sharks (Rhizoprionodon terraenovae) and 31 bonnethead sharks (Sphyrna tiburo) from the western Atlantic, and 30 spiny dogfish sharks (Squalus acanthias) from the eastern Pacific. All animals were captured during June-July 2009 and 2010. Median values and preliminary reference intervals were calculated for hematology, plasma biochemistry, trace nutrients, and vitamin A, E, and D concentrations. Significant differences, attributable to physiologic differences among the species, were found in the basic hematologic and plasma biochemistry variables. Significant species differences in arsenic and selenium plasma concentrations were found and appear to coincide with diet and habitat variability among these three species. Vitamin E was significantly higher in the bonnethead shark, again related to the foraging ecology and ingestion of plant material by this species. The Atlantic sharpnose had significantly higher vitamin A concentrations, supported by the higher proportion of teleosts in the diet. Vitamin D was below the limit of quantification in all three species. These preliminary reference intervals for health variables can be used to assess and monitor the population health and serve as indicators of nutritional status in these populations of wild elasmobranchs.

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“…A value of ÿ2 P ln P greater than the corresponding c 2 value allows us to reject the null hypothesis of no effect. We used a Bonferroni-corrected critical significance level to correct for the familywise error rate when a family of related tests was performed (Chandler 1995). Table 1 presents the results of the dominance analyses.…”

Section: Other Analysesmentioning

confidence: 99%

Dominance, fatness and fitness in female American bison, Bison bison

2005

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Practical considerations in the use of simultaneous inference for multiple tests

Cited by 213 publications

References 0 publications

Metal interactions within and between tissues of nestling rooks Corvus frugilegus

Metal interactions within and between tissues of nestling rooks Corvus frugilegus

Baseline Health Parameters and Species Comparisons Among Free-Ranging Atlantic Sharpnose (Rhizoprionodon Terraenovae), Bonnethead (Sphyrna Tiburo), and Spiny Dogfish (Squalus Acanthias) Sharks in Georgia, Florida, and Washington, Usa

Dominance, fatness and fitness in female American bison, Bison bison

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