This research examines quantum key distribution and its applications in guided and unguided quantum communication. The importance of secure communication in the quantum era requires a thorough exploration of both guided and unguided quantum communication strategies. The research aims to address the challenges posed by guided channels, such as fiber optics, and unguided channels, such as free‐space quantum communication. This study addresses existing knowledge gaps in quantum error resilience management and signal processing techniques in unguided quantum communication. Advanced quantum gate analysis, environmental noise analysis, and quantum channel modeling techniques are employed. The research presents key findings on the impact of gate imperfections on quantum error resilience in guided media, the influence of noise‐induced errors in unguided media, and a unified metric for assessing various error sources in guided channels. Additionally, the study analyses stabilizer codes and surface codes for error mitigation through quantum error correction strategies. Simulation results provide a benchmark for theoretical predictions and guide the refinement of quantum communication protocols. In this context, machine learning‐based error prediction is introduced as a cutting‐edge approach to enhance the robustness of quantum communication systems.