Deterioration of mineralogical and physical characteristics of mineral raw materials results in the formation of the primary task for the comminution processes—reduction in the size of ore to obtain a material with a certain granulometric composition, which in turn is achieved by overgrinding of raw materials and, consequently, an increase in energy costs. The work aimed to justify the possibility of selective disintegration of mineral assemblages of polymetallic ores of various genesis at the stage of crushing based on in-depth investigation and revealing of interrelation and mutual influence of mineralogical-geochemical features, textural-structural and technological properties. Structural and textural features have been studied by the methods of computed X-ray microtomography. Experimental and theoretical investigations of mineralogical and technological parameters of raw materials, as well as research on crushing using different types of crushers, made it possible to substantiate the possibility of selective disintegration for polymetallic ores.