Sexual function, including erectile function in men, is increasingly moving into the foreground in the care of patients with renal cell carcinoma (RCC). Historically, metastatic RCC had a rather poor prognosis, due to ineffective therapies, with a median overall survival of approximately 1 year (Motzer et al., 2007). The advent of targeted agents over a decade ago has dramatically improved survival and quality of life (QoL) in patients with advanced disease (Hsieh et al., 2017). Systemic treatment in advanced RCC patients usually comprises multiple sequential treatment lines including antiangiogenic therapy (AAT), most commonly inhibitors of tyrosine kinases (TKI) or the mammalian target of rapamycin (mTOR-inh). In addition, immune checkpoint inhibitors were recently approved for the treatment of metastatic kidney cancer (Hsieh et al., 2017). The effect of AAT on sexuality and erectile function in patients with RCC has been addressed in prior studies. A recent longitudinal study including both men and women described a decrease in several