Practical Issues in the Clinical Application of Mismatch Negativity

Ah, Lang; Eerola, Osmo; Korpilahti, Pirjo; Holopainen, I.; Salo, S.; Aaltonen, Olli

doi:10.1097/00003446-199502000-00009

Cited by 154 publications

(140 citation statements)

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“…The film audio was kept at usual levels, but below 40 dBNPS (A scale). 14,12 AEPs were acquired, amplified, digitalized, promediated only, and filtered by a 25 Hz low-pass filter and a 1.67Hz high-pass filter. The recording window was 60ms prior to stimulation and 480ms after stimulation.…”

Section: Methodsmentioning

confidence: 99%

“…11 The MMN reflects automatic pre-attention auditory discrimination and the activation of echoic memory. 12 It is the subtraction of auditory event-related potentials (AERP) obtained for a standard stimulus minus the AERP obtained for the deviant stimulus. 13 It is usually obtained using an oddball paradigm in which a repetitive standard stimulus is occasionally replaced by a deviant stimulus.…”

Section: Introductionmentioning

confidence: 99%

“…but also by complex stimuli, including speech. 12 An important feature of these AEPs are the fact that they are generated independently of the subject's attention, 11,14,15 making it a valuable objective measure of auditory discrimination. 10,15 Although there have been many published studies on MMN, up to the present there is a single case study 17 in which MMN was investigated in a patient with (C)APD and no other associated conditions.…”

Section: Introductionmentioning

confidence: 99%

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O Mismatch Negativity em pacientes com distúrbios do processamento auditivo (central)

Roggia

Colares

2008

Rev. Bras. Otorrinolaringol.

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O Mismatch Negativity (MMN) é um potencial evocado auditivo de longa latência que fornece uma medida objetiva das habilidades de discriminação e memória sensorial auditiva. Assim, pode ser utilizado como uma avaliação eletrofisiológica do processamento auditivo (central). OBJETIVO: Estudar o MMN em pacientes com Distúrbios do Processamento Auditivo (Central) - DPA(C). FORMA DO ESTUDO: Clínico prospectivo. MATERIAL E MÉTODO: Foram avaliados oito sujeitos com DPA(C), na faixa etária de nove a 14 anos, bem como um grupo controle. O MMN foi eliciado para estímulos tonais (tone bursts) diferindo quanto à freqüência (MMNf - estímulo padrão: 750Hz e estímulo diferente: 1000Hz ), bem como quanto à duração (MMNd - estímulo padrão: 100 ms e estímulo diferente: 50 ms; na freqüência de 1000Hz). RESULTADOS: A presença do MMNf e do MMNd foi comprovada estatisticamente em ambos os grupos estudados. Não foram constatadas diferenças significantes estatisticamente entre os valores de latência e de amplitude do MMNf e do MMNd obtidos nos dois grupos. Também não foram verificadas diferenças significantes estatisticamente entre o MMNf e o MMNd em nenhum dos grupos estudados. CONCLUSÃO: Os sujeitos com DPA(C) avaliados não apresentaram alterações no MMNf, nem no MMNd.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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O Mismatch Negativity em pacientes com distúrbios do processamento auditivo (central)

Roggia

Colares

2008

Rev. Bras. Otorrinolaringol.

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“…It has been emphasized by different authors (Kurtzberg et al, 1995;Lang et al, 1995;McGee et al, 1997) that it is necessary to improve the SNR of the MMN in order to reach a suf®cient reliability. So far the usual way to do this is to enlarge the number of deviants that are averaged.…”

Section: Erp Measuresmentioning

confidence: 99%

“…However, the possibility to apply this method is very limited in children. Let alone practical problems, Lang et al (1995) observed that MMN amplitudes decreased during longer experimental sessions in young adults. Other methods, e.g.…”

Section: Erp Measuresmentioning

confidence: 99%

Stability of mismatch negativities in children

Uwer¹,

Suchodoletz²

2000

Clinical Neurophysiology

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Objectives and methods: Mismatch negativities (MMN) to frequency and duration changes in a series of repetitive tones and to two different consonant-vowel syllables (ba and ga, standard da) were recorded in a test and retest session in 15 children aged 7±11 years. Reliability within one session and stability between the sessions of MMN amplitudes and the ERP-components P1 and N1 were determined by correlation coef®cients.Results: Mean amplitudes of the grand averages showed a decrease of MMN during the second test session in a late latency window (400± 500 ms) for the frequency MMN and of the MMN elicited by speech stimuli. The individual stability reached signi®cance only for the duration deviant and one of the syllables. Compared to results found in adults with similar stimulus conditions the stability of the MMN in children seems to be somewhat lower. The components P1 and N1 to both stimulus types (tone and speech), however, showed a high reliability and individual stability.Conclusion: While MMN is a useful tool to study processing de®cits in groups of children, as e.g. in language-impaired children, MMN as a individual diagnostic measure should be interpreted very cautiously. q

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Mismatch Negativity Deficits Are Associated With Poor Functioning in Schizophrenia Patients

Light¹,

Braff²

2005

Arch Gen Psychiatry

374

321

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This pattern of results suggests that MMN deficits represent a core neurophysiological dysfunction that is linked to global impairments in everyday functioning in schizophrenia patients. These deficits in automatic preattentive information processing account for up to 42% of the variance in global functional status in schizophrenia patients. Thus, basic preattentional cognitive deficits may be excellent measures for predicting functional outcome. Longitudinal studies are needed to better understand the relationships between deficits in automatic sensory information processing, associated neural substrate dysfunctions, and deficits in everyday functioning across the course of the illness.

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Practical Issues in the Clinical Application of Mismatch Negativity

Cited by 154 publications

References 0 publications

O Mismatch Negativity em pacientes com distúrbios do processamento auditivo (central)

O Mismatch Negativity em pacientes com distúrbios do processamento auditivo (central)

Stability of mismatch negativities in children

Mismatch Negativity Deficits Are Associated With Poor Functioning in Schizophrenia Patients

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