Practical Parthenote Policy and the Practice of Science

Campo‐Engelstein, Lisa; Rodrı́guez, S.; Tingen, Candace; Woodruff, Teresa K.

doi:10.1080/15265161.2011.563162

Cited by 6 publications

(8 citation statements)

References 8 publications

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“…The predictive quality of the zinc spark as a marker of the developmental potential of human zygotes, however, is not readily evaluated due to ethical, legal and technical considerations regarding human embryo research. We therefore used a mouse model to determine whether zinc spark profiles are correlated with preimplantation embryo development 14 15 16 . We measured zinc spark profiles in individual mouse eggs following parthenogenetic activation or in vitro fertilization (IVF) and tracked the development of the resulting parthenotes and embryos, respectively.…”

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confidence: 99%

The fertilization-induced zinc spark is a novel biomarker of mouse embryo quality and early development

Zhang

Duncan

Que

et al. 2016

Sci Rep

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Upon activation, mammalian eggs release billions of zinc ions in an exocytotic event termed the “zinc spark.” The zinc spark is dependent on and occurs coordinately with intracellular calcium transients, which are tightly associated with embryonic development. Thus, we hypothesized that the zinc spark represents an early extracellular physicochemical marker of the developmental potential of the zygote. To test this hypothesis, we monitored zinc exocytosis in individual mouse eggs following parthenogenetic activation or in vitro fertilization (IVF) and tracked their development. Retrospective analysis of zinc spark profiles revealed that parthenotes and zygotes that developed into blastocysts released more zinc than those that failed to develop. Prospective selection of embryos based on their zinc spark profile significantly improved developmental outcomes and more than doubled the percentage of embryos that reached the blastocyst stage. Moreover, the zinc spark profile was also associated with embryo quality as the total cell number in the resulting morulae and blastocysts positively correlated with the zinc spark amplitude (R = 0.9209). Zinc sparks can thus serve as an early biomarker of zygote quality in mouse model.

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confidence: 99%

The fertilization-induced zinc spark is a novel biomarker of mouse embryo quality and early development

Zhang

Duncan

Que

et al. 2016

Sci Rep

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“…Such apprehensions have unfortunately translated into federal restrictions on the funding of reproductive research-in particular research concerning human embryos. Such restrictions began in the 1970s shortly after the legalization of abortion and were reinforced in 1996 with the passage of the Dickey Wicker Amendment [34][35][36].…”

Section: Discussionmentioning

confidence: 99%

A small field for fertile science: the low visibility of reproductive science in high impact journals

Duncan

Derman

Woodruff

2014

J Assist Reprod Genet

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Purpose Our success as a field and as individuals in reproductive science and medicine relies on our ability to produce high quality work that has broad visibility and impact. A common metric for assessing such success is the quantity of publications that are published in journals with high impact factors. It is unclear, however, how frequently work related to reproductive science and medicine actually appears in what are considered the highest impact journals. Methods To address this gap in knowledge, we first determined how the field of reproductive biology in general compared to other research areas in terms of composite journal impact factor. Second, using a targeted search approach in the PubMed database, we examined the relationship between a journal's impact factor and the number of reproductive research articles published per journal issue. Results We found that compared to other major scientific disciplines, our field lacks journals with impact factors above 4. In addition, primary original research articles on reproductionirrespective of male or female search terms-do not appear often in high impact journals. Instead, there is an increased percentage of secondary reproductive literature in high impact journals compared to topic-specific journals of lower impact. Conclusions There are likely several explanations for why reproductive science and medicine has low visibility, including the field's small relative size, its lack of a specific disease and associated strong advocacy, and its surrounding social, ethical, and political unease. Nevertheless, there are concrete actions we can take to minimize the role of impact factor in our evaluation while simultaneously increasing influence through global awareness of the importance and need for reproductive research.

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“…In one analysis, female cancer survivors were more likely to have clinical infertility (>1 year of attempts to conceive) and the risk increased with exposure to increasing doses of radiation and chemotherapy with alkylating agents (Green et al . 2009 a , 2011, Barton et al . 2013).…”

Section: Minding the Gapsmentioning

confidence: 99%

“…We have matured eggs from human follicles (Xiao and T Woodruff unpublished observations) but have not fertilized or activated these eggs because of legal restrictions regarding the use of human gametes for research in the USA (Tingen et al . 2010, Campo-Engelstein et al . 2011, Rodriguez et al .…”

Section: Advances In Ovarian Follicle Culturementioning

confidence: 99%

Oncofertility: a grand collaboration between reproductive medicine and oncology

Woodruff¹

2015

Reproduction

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In 2007, I was asked by the University of Calgary to participate in a symposium called ‘Pushing the Boundaries – Advances that Will Change the World in 20 Years’. My topic was oncofertility, a word I had just coined to describe the intersection of two disciplines – oncology and fertility – and I was thrilled to share my passion for this new field and help young women with cancer protect their future reproductive health. Fertility preservation in the cancer setting lacked a concerted effort to bridge the disciplines in an organized manner. In early 2015, I was delighted to deliver a presentation for the Society for Reproduction and Fertility titled ‘Sex in Three Cities’, where I gave an update on the oncofertility movement, a remarkable cross-disciplinary, global collaboration created to address the fertility preservation needs of young cancer patients. During my tour of the UK, I was impressed by the interest among the society and its members to engage colleagues outside the discipline as well as the public in a dialogue about cutting-edge reproductive science. In this invited review, I will describe the work of the Oncofertility Consortium to provide fertility preservation options in the cancer setting and accelerate the acceptance of this critical topic on a global scale. I hope that one day this word and field it created will change the world for women who had been left out of the equation for far too long.

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Practical Parthenote Policy and the Practice of Science

Cited by 6 publications

References 8 publications

The fertilization-induced zinc spark is a novel biomarker of mouse embryo quality and early development

The fertilization-induced zinc spark is a novel biomarker of mouse embryo quality and early development

A small field for fertile science: the low visibility of reproductive science in high impact journals

Oncofertility: a grand collaboration between reproductive medicine and oncology

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