Practical pattern of surgical timing of childhood cataract in China: A cross-sectional database study

Lin, Duoru; Liu, Zhenzhen; Chen, Jingjing; Lin, Zhuoling; Chen, Chuan; Wu, Mingxing; Chen, Weirong; Liu, Yizhi

doi:10.1016/j.ijsu.2019.01.012

Cited by 4 publications

(6 citation statements)

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“…On account of the rarity and exceptionality of CC patients, there is no consensus regarding the surgery time and surgery type for CC, which remain controversial worldwide. CCPMOH is a hospitalbased national program with the largest clinical database of CC patients (Lin et al, 2015), based on data of 2421 patients from which, a ZOC team constructed a CC surgical decision model (Lin D. et al, 2019). The model can potentially serve as an objective basis for ophthalmologists to decide on surgical plans after more validations.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, other ocular parameters, including anterior chamber depth and capsular size, can be included in the model to improve its accuracy and general applicability. As most IOLs are designed for adults and too large for children, severe deformities of the anterior and posterior capsula were observed in 30% of CC patients with IOL, which potentially led to IOL eccentricity and dislocation (Lin D. et al, 2019). The model with capsular-associated parameters may have a higher applied effectiveness.…”

Section: Discussionmentioning

confidence: 99%

“…A retrospective study was conducted from December 2018 to June 2020 at the Zhongshan Ophthalmic Center (ZOC), Guangdong, China. The RWD was collected from a national project for CC treatment and research, the Childhood Cataract Program of the Chinese Ministry of Health (CCPMOH) (Lin D. et al, 2019). This study followed the tenets of the Declaration of Helsinki and was approved by the Institutional Review Board of the ZOC at Sun Yat-sen University (IRB-ZOC-SYSU).…”

Section: Methodsmentioning

confidence: 99%

“…The CC surgical type decision model was established based on the data of 2421 CC patients recruited over 10 years from 1 January 2005 to 31 December 2014 (Lin D. et al, 2019). The original research aimed to provide timings of CE and IOL implantation for CC patients based on large-scale clinical experience, and to serve as a guidance for ophthalmologists to make treatment strategies.…”

Section: Surgical Type Decision Modelmentioning

confidence: 99%

“…RWD is from patient medical chart reviews and registries rather than conventional randomized controlled trials (Elliott et al, 2016;Goldstein et al, 2019), which has been acknowledged as more favorable and valuable for guiding medical decisions (Goulooze et al, 2020). Published study has achieved a surgical decision model for a rare disease, childhood cataract (CC) (Lin D. et al, 2019). In our study, we collected RWD from 251 patients with CC and conducted a retrospective study to validate the CC surgical decision model.…”

Section: Introductionmentioning

confidence: 99%

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Application of Surgical Decision Model for Patients With Childhood Cataract: A Study Based on Real World Data

Chen

Xiang

et al. 2021

Front. Bioeng. Biotechnol.

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Reliable validated methods are necessary to verify the performance of diagnosis and therapy-assisted models in clinical practice. However, some validated results have research bias and may not reflect the results of real-world application. In addition, the conduct of clinical trials has executive risks for the indeterminate effectiveness of models and it is challenging to finish validated clinical trials of rare diseases. Real world data (RWD) can probably solve this problem. In our study, we collected RWD from 251 patients with a rare disease, childhood cataract (CC) and conducted a retrospective study to validate the CC surgical decision model. The consistency of the real surgical type and recommended surgical type was 94.16%. In the cataract extraction (CE) group, the model recommended the same surgical type for 84.48% of eyes, but the model advised conducting cataract extraction and primary intraocular lens implantation (CE + IOL) surgery in 15.52% of eyes, which was different from the real-world choices. In the CE + IOL group, the model recommended the same surgical type for 100% of eyes. The real-recommended matched rates were 94.22% in the eyes of bilateral patients and 90.38% in the eyes of unilateral patients. Our study is the first to apply RWD to complete a retrospective study evaluating a clinical model, and the results indicate the availability and feasibility of applying RWD in model validation and serve guidance for intelligent model evaluation for rare diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Surgical Type Decision Modelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Application of Surgical Decision Model for Patients With Childhood Cataract: A Study Based on Real World Data

Chen

Xiang

et al. 2021

Front. Bioeng. Biotechnol.

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Appropriate addition power for aphakic infants determined by a smart wearable device Clouclip

Liu,

Wen,

Sun

et al. 2024

Clinical and Experimental Optometry

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Congenital cataract case series

Aygıt

2021

Ege Tıp Dergisi

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Amaç: Bu çalışmamızda konjenital katarakt nedeniyle hastanemize başvuran hastaların başvuru yaşı, operasyon zamanı, uygulanan cerrahi teknik ve intraoküler lens implantasyonu, posterior kapsül kesafeti ve elde edilen görsel sonuçların değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Hastanemizde, 2016-2017 yılları arasında konjenital katarakt cerrahisi geçirmiş hasta dosyaları retrospektif olarak incelenmiştir. Çalışmamıza 25 (16 erkek, 9 kız) hastanın 42 (24 sağ, 18 sol) gözü dahil edilmiştir. Altı aydan kısa takip süresi olan hastalar çalışmaya dahil edilmemiştir. Vakaların demografik özellikleri, elde edilen en iyi düzeltilmiş görme keskinlikleri ve ön segment bulguları kaydedilmiştir. İstatistiksel analizler SPSS programı ile yapılmıştır. Bulgular: Yaş ortalaması 6,5±3 yıl (3-12) ve ortalama takip süreleri 2,7 yıl (2-3,5) idi. Bir yıllık süre içinde 17 hastaya bilateral, sekiz hastaya unilateral konjenital katarakt cerrahisi yapılmıştır. Tüm hastalara ko-aksiyel irrigasyon aspirasyon ile lens aspirasyonu, primer posterior kapsüloreksis, anterior vitrektomi ve intraoküler lens implantasyonu uygulanmıştır. Takiplerde 23 hastada ambliyopi tespit edilmiştir. Sonuç: Kongenital katarakt gelişmekte olan ve az gelişmiş ülkelerde çocukluk çağı körlüklerinin önemli bir nedenidir. Bu nedenle görme gelişimi açısından konjenital katarakt hastalarının tespit edilmesi, cerrahi zamanlama, cerrahi teknik ve hastaların düzenli takiplerinin yapılması önemlidir.

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Practical pattern of surgical timing of childhood cataract in China: A cross-sectional database study

Cited by 4 publications

References 33 publications

Application of Surgical Decision Model for Patients With Childhood Cataract: A Study Based on Real World Data

Application of Surgical Decision Model for Patients With Childhood Cataract: A Study Based on Real World Data

Appropriate addition power for aphakic infants determined by a smart wearable device Clouclip

Congenital cataract case series

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