Practical synthesis of water-soluble organic nanoparticles with a single reactive group and a functional carrier scaffold

Bai, Yugang; Xing, Hang; Vincil, Gretchen A.; Henderson, Essence J.; Lu, Yi; Lemcoff, N. Gabriel; Zimmerman, Steven C.

doi:10.1039/c4sc00700j

Cited by 65 publications

(81 citation statements)

References 48 publications

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“…166 The method involved the ring-opening metathesis polymerization of a norbornene dicarboxyimide monomer carrying an activated ester group (N-hydroxy succinimide ester) using Grubbs third-generation catalyst. The activated ester groups of the ROMP-derived polymer were then grafted with tris-(allyloxymethyl)aminomethane to produce a large number of terminal olefin groups across the polymer chain.…”

Section: Nitrene Insertion/couplingmentioning

confidence: 99%

Intramolecular Cross-Linking Methodologies for the Synthesis of Polymer Nanoparticles

et al. 2015

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Section: Nitrene Insertion/couplingmentioning

confidence: 99%

Intramolecular Cross-Linking Methodologies for the Synthesis of Polymer Nanoparticles

et al. 2015

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“…For example, a ring closing metathesis (RCM) reaction was used as the driving force for the collapse of single polymer chain. 94 …”

Section: Single-chain Polymeric Nanoparticles (Scnps)mentioning

confidence: 99%

Self-assembly of random copolymers

et al. 2014

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Self-assembly of random copolymers has attracted considerable attention recently. In this feature article, we highlight the use of random copolymers to prepare nanostructures with different morphologies and to prepare nanomaterials that are responsive to single or multiple stimuli. The synthesis of single-chain nanoparticles and their potential applications from random copolymers are also discussed in some detail. We aim to draw more attention to these easily accessible copolymers, which are likely to play an important role in translational polymer research.

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“…They are synthesized, generally at high dilution (∼ 1 mg/mL), through purely intramolecular cross-linking of the reactive functional groups of single polymer precursors. A growing interest is being devoted in recent years to develop a SCNPbased technology with multiple applications in catalysis [6][7][8][9] , nanomedicine 10,11 , bioimaging 12,13 , biosensing 14 , or rheology [15][16][17] among others. A recent review of the state-of-the-art in fundamentals and applications of SCNPs can be found in Ref.…”

Section: Introductionmentioning

confidence: 99%

Effects of precursor topology and synthesis under crowding conditions on the structure of single-chain polymer nanoparticles

Formanek

Moreno

2017

Soft Matter

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By means of molecular dynamics simulations we investigate the formation of single-chain nanoparticles through intramolecular cross-linking of polymer chains, in the presence of their precursors acting as purely steric crowders in concentrated solution. In the case of the linear precursors, the structure of the resulting SCNPs is weakly affected by the density at which the synthesis is performed. Crowding has significant effects if ring precursors are used: higher concentrations lead to the formation of SCNPs with more compact and spherical morphologies. Such SCNPs retain in the swollen state (high dilution) the crumpled globular conformations adopted by the ring precursors in the crowded solutions. Increasing the concentration of both the linear and ring precursors up to 30 % leads to faster formation of the respective SCNPs.

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Practical synthesis of water-soluble organic nanoparticles with a single reactive group and a functional carrier scaffold

Abstract: A practical synthesis of biocompatible organic nanoparticles with a reactive group and a functional carrier scaffold was developed.

Cited by 65 publications

References 48 publications

Intramolecular Cross-Linking Methodologies for the Synthesis of Polymer Nanoparticles

Intramolecular Cross-Linking Methodologies for the Synthesis of Polymer Nanoparticles

Self-assembly of random copolymers

Effects of precursor topology and synthesis under crowding conditions on the structure of single-chain polymer nanoparticles

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