The purpose of this study was to evaluate the effects of primers on the bond strength and durability of an acrylic resin luting agent bonded to zirconia. Disk specimens were fabricated from zirconia partially stabilized with yttrium oxide. The disks were primed with one of the following materials: Alloy Primer (AP), Ceramic Primer (CP), Liquid A of the Porcelain Liner M (PLM-A), Liquid B of Porcelain Liner M (PLM-B), Porcelain Liner M (PLM-A+PLM-B), Monobond Plus (MP), and mixture of AP and PLM-B. The specimens were bonded with a tri-n-butylborane (TBB)-initiated luting agent. The shear bond strengths were determined both before and after thermocycling. The results were statistically analyzed with a non-parametric procedure. The highest post-thermocycling bond strength was generated from the groups primed with MP, CP, and AP. It can be concluded that the application of three phosphate primers is recommended for bonding the zirconia with the TBB-initiated luting agent.