Practice Bulletin No. 138

doi:10.1097/01.aog.0000433981.36184.4e

Cited by 215 publications

(36 citation statements)

References 30 publications

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“…However, they were not able to show any statistically significant difference for PS. From their data Paidas et al [5,6] proposed cut-off values for FPS. Authors identified 30 and 25 % cut-off values for FPS in the second and third trimesters, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Theoretically, this decrease in protein S (PS) and FPS levels may also be offered to cause predisposition to thrombosis and PVD. In order to differentiate between normal and abnormal during pregnancy cut-off values had been previously proposed for clinical use [5,6]. However, reference curves for the gestational age in weeks for FPS haven't been established.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Free Protein S Reference Ranges in Gravidas Without Hereditary and Acquired Thrombophilia

Başaran¹,

Deren

Büyükaşık

et al. 2014

Indian J Hematol Blood Transfus

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We carried out a retrospective cohort study to construct reference ranges for free protein S (FPS) levels during pregnancy and identify any conditions or factors that may affect FPS levels. Patients that were ordered thrombophilia screening tests during gestational period were identified. Patients demonstrated to have hereditary or acquired thrombophilia were excluded. Reference ranges were constructed using regression analysis. Outcome of the index pregnancy and pregnancy complications was used to identify any confounding factors. A total of 455 pregnant women were included. The quadratic equation for FPS according to gestational age (GA) was [75.497 + (-1.516*GA) + 0.018*GA*GA]. FPS level and GA were negatively correlated (Spearmans rho statistic [rs] = -0.436, p = 0.001). FPS level and fetal growth restriction (FGR) were negatively correlated ([rs] = -0.093, p = 0.049). FPS level and placental abruption were positively correlated ([rs] = 0.098, p = 0.039). Stepwise linear regression model constructed to predict FPS level with gestational age, placental abruption and FGR as the predictor variables. Gestational age was the only variable retaining statistically significant relation with FPS level (χ(2) = 0.216, df = 3, p = 0.001). FPS levels decrease significantly throughout gestation in gravidas without hereditary and/or acquired thrombophilias. In patients without thrombophilia FPS levels are not associated with pregnancy complications. The obtained reference intervals may be useful for the clinicians ordering FPS during pregnancy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Free Protein S Reference Ranges in Gravidas Without Hereditary and Acquired Thrombophilia

Başaran¹,

Deren

Büyükaşık

et al. 2014

Indian J Hematol Blood Transfus

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“…Moreover, the risk of a thromboembolic event during pregnancy has been shown to differ according to the nature of the thrombophilia, with estimates of risk varying from 5 to 33 % [5]. Nevertheless, the routine screening of all pregnant women to identify those with thrombophilias has not been recommended and antenatal prophylaxis for all women with known thrombophilias remains controversial [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Low-molecular-weight heparin plus aspirin versus aspirin alone in pregnant women with hereditary thrombophilia to improve live birth rate: meta-analysis of randomized controlled trials

Areia

Fonseca

Areia

et al. 2015

Arch Gynecol Obstet

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“…We also identified 70 specific situations guidelines published between 2002 and 2014. Of these, 91% were from the USA,25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59 UK60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76 and Canada 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88. The remaining were from Australia,89 Brazil,90 Mexico,91 Poland,92 Spain93 and Uruguay 94…”

Section: Resultsmentioning

confidence: 99%

Antenatal care for healthy pregnant women: a mapping of interventions from existing guidelines to inform the development of new WHO guidance on antenatal care

Ábalos

Chamillard

Díaz

et al. 2015

BJOG

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BackgroundThe World Health Organization (WHO) is in the process of updating antenatal care (ANC) guidelines.ObjectivesTo map the existing clinical practice guidelines related to routine ANC for healthy women and to summarise all practices considered during routine ANC.Search strategyA systematic search in four databases for all clinical practice guidelines published after January 2000.Selection criteriaTwo researchers independently assessed the list of potentially eligible publications.Data collection and analysisInformation on scope of the guideline, type of practice, associated gestational age, recommendation type and the source of evidence were mapped.Main resultsOf 1866 references, we identified 85 guidelines focusing on the ANC period: 15 pertaining to routine ANC and 70 pertaining to specific situations. A total of 135 interventions from routine ANC guidelines were extracted, and categorised as clinical interventions (n = 80), screening/diagnostic procedures (n = 47) and health systems related (n = 8). Screening interventions, (syphilis, anaemia) were the most common practices. Within the 70 specific situation guidelines, 102 recommendations were identified. Overall, for 33 (out of 171) interventions there were conflicting recommendations provided by the different guidelines.ConclusionMapping the current guidelines including practices related to routine ANC informed the scoping phase for the WHO guideline for ANC. Our analysis indicates that guideline development processes may lead to different recommendations, due to context, evidence base or assessment of evidence. It would be useful for guideline developers to map and refer to other similar guidelines and, where relevant, explore the discrepancies in recommendations and others.Tweetable abstractWe identified existing ANC guidelines and mapped scope, practices, recommendations and source of evidence.

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Practice Bulletin No. 138

Cited by 215 publications

References 30 publications

Free Protein S Reference Ranges in Gravidas Without Hereditary and Acquired Thrombophilia

Free Protein S Reference Ranges in Gravidas Without Hereditary and Acquired Thrombophilia

Low-molecular-weight heparin plus aspirin versus aspirin alone in pregnant women with hereditary thrombophilia to improve live birth rate: meta-analysis of randomized controlled trials

Antenatal care for healthy pregnant women: a mapping of interventions from existing guidelines to inform the development of new WHO guidance on antenatal care

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