“…Mohs surgeons vary in techniques to assess MMS margins, including the use of IHC and whether to excise an additional peripheral margin for permanent sections after MMS. Similar to survey data, 7,8 a majority (67%, 16/24) of centers evaluate margins with IHC, 10,12,14,15,17–25,27,28,32 most commonly with MART-1. Frozen sections with melanocytic IHC detect melanoma as accurately as permanent sections, 47,50 have a higher sensitivity and specificity for detecting melanoma compared with H&E stains, 51,52 and may result in fewer stages and simpler reconstruction.…”