Vocal fold leukoplakia (VFL) has a risk of malignant transformation. Therefore,
patients can have symptoms such as dysphonia, vocal strain, difficulty
breathing, and dysphagia. Additionally, there is a genetic predisposition that
can be associated with genetic polymorphisms. We aimed to evaluate the influence
of genetic polymorphisms and protein levels in the etiology of VFL. Our study
followed the PRISMA checklist and was registered on PROSPERO database. The
questions were: “Are genetic polymorphisms involved in the etiology of VFL? Are
protein levels altered in patients with VFL?”. Eligibility criteria were case
control studies that compared the presence of polymorphisms or/and protein
levels of subjects diagnosed with VFL and healthy controls. Of the 905 articles
retrieved, five articles with a total of 1038 participants were included in this
study. The C allele of the single nucleotide polymorphisms (SNP)-819 T/C
IL-10
, A allele of the SNP -592 A/C
IL-10
,
CT genotype of the SNP rs11886868 C/T
BCL11A
, GG genotype of
the SNP rs4671393 A/G
BCL11A
, LL genotype, and L allele of
(GT)n repeat polymorphisms of the
HO-1
were risk factors for
VFL development. Nevertheless, there was a lack of association between VFL and
the -1082 A/G
IL-10
, rs14024
CK-1
, and -309
T/G
Mdm2
SNPs. The concentrations of the MDM2, BCL11A, and HO-1
proteins were modified, while IL-10 levels were normally expressed in these
subjects. In conclusion, most markers evaluated in this review could be
potential indicators to develop effective therapies, avoiding a malignant
transformation of the lesion.