Background: Approximately, half a million of adolescent girls in the world feel frustrated during their monthly period due to poor menstrual hygiene practices. In the low-and-middle income countries, about three-quarters of girls do not have access to clean sanitary materials, and use low-quality products. In the Sub-Saharan African countries, menstruation among schoolage girls is a neglected issue. Poor menstrual hygiene practices expose adolescent girls to reproductive organ infections, psychosocial stress, and poor school attendance. However, the available data concerning challenges associated with menstrual hygiene among school girls in the remote areas of Kenya remains unknown. Aim: To assess challenges associated with menstrual hygiene among adolescent girls attending Bocharia Primary School in Nyamira County, Kenya. Methods: The target population was grade 4 to 8 adolescent girls (n = 111) aged 10 -19 years. Hence, census method of sampling was used to include all the girls in grade 4 -8. Raw data was obtained using a Semi-structured questionnaire which was tested by a representation of 11 girls (10% of the sample size) who had the same characteristics. Data was analyzed using SPSS version 21 with both descriptive and inferential statistics. In descriptive statistics, frequency and percentage were generated. The chi-square test of independence was used to determine associations between some socio-demographic variables of the girls and menstrual hygiene practice. A p-value of less than 0.05 was considered to be significant. Results: The study found that majority (57%) of the respondents had poor menstrual hygiene practices associated with lack of accessibility and affordability to sanitary products, functional and safe latrines, shortage of soap and water supply, and sanitation facilities. Approximately half (47.8%) of the respondents reported that menstrual hygiene practices are highly influenced by taboo from cultural beliefs and societal norms. Girls who live with both parents were How to cite this paper: Manyara, M.B., and Okube, O.T.