Uncomplicated urinary tract infections (uUTIs) are among the more common bacterial infections in children. Despite their prevalence, significant variability exists in the treatment duration and antibiotic selection for uUTI. 1 Emerging evidence in the pediatric literature suggests a shorter duration of antibiotics for uUTIs is both efficacious and safe. [2][3][4][5][6] Clinical guidelines from the United Kingdom, Australia and New Zealand recommend 3 days of antibiotic therapy for children 3 months and older with uUTI. 3,4 A large, multicenter, randomized, double-blind, placebo-controlled trial of children aged 2 to ten years evaluating 5 days compared with ten days of treatment showed treatment success in 96% of children who received 5 days of treatment and no significant differences in recurrent infection or adverse events between groups. 5 Three days of treatment duration is strongly supported in the literature on adult female patients with multiple prospective randomized controlled trials showing equal efficacy with longer treatment duration. [7][8][9] The Infectious Diseases Society of America recommends 3 days of antibiotic therapy for uUTI in adult women. 10 Shorter treatment for uUTIs may reduce healthcare costs, antimicrobial resistance, the risk of drug-related toxicity and/or adverse effects, and increase patient adherence to prescribed regimens. 11 Treatment of pediatric uUTIs with first-generation cephalosporins is efficacious with low rates of antimicrobial resistance. 12,13