Practolol in the Treatment of Cardiac Dysrhythmias Due to Acute Myocardial Infarction

Jewitt, D. E.; Mercer, C.J.; Shillingford, John

doi:10.1016/s0140-6736(69)90001-4

Cited by 66 publications

(18 citation statements)

References 11 publications

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“…Data are reproducible, and furthermore the effective dose of lignocaine in this test (c. 1 mg/kg) is comparable with the dose in man required to revert some types of arrhythmias (Jewitt, Kishon & Thomas, 1968). On the other hand, practolol, a drug known to be effective in the treatment of some types of cardiac arrhythmias (Jewitt et al, 1969a;Allen, Pantridge & Shanks, 1971), was ineffective in this test even at the high doses ultimately infused. The lack of activity of practolol in reverting an established ouabain arrhythmia is in agreement with the data of Dunlop & Shanks (1968).…”

Section: Discussionsupporting

confidence: 53%

A COMPARISON OF THE EXPERIMENTAL ANTI‐ARRHYTHMIC PROPERTIES OF ACEBUTOLOL: (M & B 17,803), PROPRANOLOL AND PRACTOLOL

Basil

Jordan

Loveless

et al. 1974

British J Pharmacology

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The β‐adrenoceptor blocking agent, acebutolol (M & B 17,803), has been compared with propranolol, practolol, lignocaine and quinidine for its ability to revert or prevent various types of experimental arrhythmias. By intravenous infusion, acebutolol had one half the potency of propranolol in reverting an established ouabain‐induced ventricular arrhythmia in the anaesthetized dog. Practolol was ineffective in the conditions used. High oral doses of acebutolol or propranolol significantly increased the arrhythmic dose of ouabain in the conscious rabbit. Similar doses of practolol produced a significant decrease (i.e. potentiation) in the dose of ouabain required to produce arrhythmia. Lignocaine and quinidine showed no or little activity in this test. Propranolol, acebutolol and practolol were all effective in decreasing the frequency of ectopic beats induced by adrenaline and methylchloroform in the anaesthetized cat. Lignocaine and quinidine were only weakly effective. Acebutolol and propranolol were equally effective either intravenously or orally in reducing the incidence of ventricular fibrillation produced by chloroform in mice. It is suggested that the wide spectrum of experimental anti‐arrhythmic activity of acebutolol coupled with its cardioselectivity may make it an interesting compound in the treatment of cardiac arrhythmias in man.

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Section: Discussionsupporting

confidence: 53%

A COMPARISON OF THE EXPERIMENTAL ANTI‐ARRHYTHMIC PROPERTIES OF ACEBUTOLOL: (M & B 17,803), PROPRANOLOL AND PRACTOLOL

Basil

Jordan

Loveless

et al. 1974

British J Pharmacology

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“…Marked elevations of both adrenaline and noradrenaline in the urine have been demonstrated, particularly in patients who develop haemodynamic complications. Analysis of the incidence of arrhythmias in these patients showed an association between high peak catecholamine excretion and the development of arrhythmias (Jewitt et al, 1969a;Jewitt and Croxson, 1971). It might therefore be expected that {3-adrenergic receptor blockade would be particularly effective in preventing or aborting arrhythmias in acute myocardial infarction.…”

Section: Effect Of Catecholaminesmentioning

confidence: 99%

“…Because its depressant effect on cardiovascular dynamics is less than that of conventional beta antagonists, it is also the agent of choice in patients who have reduced myocardial performance. Like propranolol, it has an established place in the management of many supraventricular and ventricular arrhythmias (Jewitt et al, 1969b;Allen et al, 1971 ;Jewitt and Croxson, 1971).…”

Section: Practololmentioning

confidence: 99%

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??-Adrenergic Receptor Blocking Drugs in Cardiac Arrhythmias1

Singh

Jewitt

1974

Drugs

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“…Beta-adrenergic blocking drugs have been shown to re duce the frequency and severity of ventricular arrhyth mias after experimental coronary artery occlusion and to increase ventricular fibrillation threshold [4][5][6], How ever, although several non-randomized [7][8][9][10][11][12] clinical studies have also suggested that intravenous beta block ers might also be effective in reducing such arrhythmias in the first 24 h after acute myocardial infarction, the results of randomized controlled clinical trials using electrocardiographic monitoring have varied [13,14], blood pressure, and QTc were all found to have reasonably normal distributions. For the remaining variables the assumption of a log normal distribution was found to be more appropriate.…”

Section: Introductionmentioning

confidence: 99%

Effects of Intravenous Sotalol on the Q-T Interval and Incidence of Ventricular Arrhythmias Early in Acute Myocardial Infarction

Ramsdale¹,

Llewellyn²,

Pidgeon³

et al. 1988

Am J Noninvas Cardiol

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Sixty-two patients with acute myocardial infarction were randomized within 12 h to either intravenous (120 mg) and oral (320 mg daily) sotalol (n = 27) or a control group (n = 35). At 20 min, heart rate and systolic blood pressure fell significantly in sotalol-treated patients (from 78 ± 13 to 59 ± 8 beats/min and from 131 ± 18 to 109 ± 21 mmHg; mean ± SD) compared to controls (from 79 ± 16 to 81 ± 15 beats/min and from 133 ± 22 to 131 ±26 mm Hg; p < 0.001). At 30 min, QTc had increased by 16.7% in sotalol-treated patients and by 3.7% in controls (p < 0.001). Twenty-four-hour ECG monitoring showed that the total number of ventricular premature beats (135 vs. 238; p < 0.05) and R on T ventricular premature beats (2.5 v.s. 7.0; p = 0.004) were fewer in sotalol-treated than in control patients. However, the frequency of ventricular couplets, triplets, and bouts of ventricular tachycardia was similar in both groups. Adverse effects of sotalol were infrequent. A large study is required to assess any prophylatic effect on primary ventricular fibrillation.

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Practolol in the Treatment of Cardiac Dysrhythmias Due to Acute Myocardial Infarction

Cited by 66 publications

References 11 publications

A COMPARISON OF THE EXPERIMENTAL ANTI‐ARRHYTHMIC PROPERTIES OF ACEBUTOLOL: (M & B 17,803), PROPRANOLOL AND PRACTOLOL

A COMPARISON OF THE EXPERIMENTAL ANTI‐ARRHYTHMIC PROPERTIES OF ACEBUTOLOL: (M & B 17,803), PROPRANOLOL AND PRACTOLOL

??-Adrenergic Receptor Blocking Drugs in Cardiac Arrhythmias1

Effects of Intravenous Sotalol on the Q-T Interval and Incidence of Ventricular Arrhythmias Early in Acute Myocardial Infarction

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