Praktische Erfahrungen bei 312 nephroangiographierten Patienten mit Hypertonie

Lohmann, Friedrich; Dissmann, T; Gotzen, R.; Molzahn, M; Oelkers, W.; Vera-Bachmann, Daniela; Grohme, S.

doi:10.1007/bf02215948

Cited by 3 publications

(1 citation statement)

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“…The malignancy rate of 6 to 20% reported by most authors [4][5][6][7][8][9][10][11][12][13][14] varies according to the definition of malignancy applied, i.e., metastasis, invasion of neighbouring organs, or invasion of organ capsules. Pheochro- Muenster, Germany mocytomas occur in less than 1 % of hypertensive individuals [15]. Early detection is imperative since a) 90% of pheochromocytomas are curable via resection; b) a rise in incidence of the disorder has been reported [16]; and c) most pheochromocytomas remain undetected during the patients' lifetime.…”

Section: Pheochromocytomasmentioning

confidence: 99%

Clinical Differences between Benign and Malignant Pheochromocytomas.

et al. 2001

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Abstract. Most pheochromocytomas can be cured by resection. In view of the unfavourable prognosis for surgical therapy in cases of late tumour detection and malignant tumours, the aim of the present study is to differentiate between typical signs and symptoms of malignant versus benign pheochromocytomas. We investigated the records of 133 patients retrospectively . In cases of benign tumours (104 of 133, mean age 42± 15.8 years) tumour size was 5.9±3.4 cm, and history was 47.4±75.4 months. 7.7% of the tumours were extraadrenal, and 77% had paroxysmal manifestations. The other 29 patients (mean age: 39.2±21.9 years) had malignant lesions (tumour size: 9.4±5.9 cm (p=0.0022); history: 7.4±5.6 months (p=0.0137); extraadrenal: 24.1% (p=0.0219); paroxysmal: 37.9% (p=0.0012)). Symptoms of patients with benign tumours were hypertension (80%), headaches (42.3%), sweating (30.8%), tachycardia (26%) and pallor (24% (Malignant: Hypertension 46%, p=0.0873; headaches 11%, p=0.0008; sweating 11 %, p=0.0196; tachycardia 14%, p = 0.1961 and pallor 0%, p=0.0010). Abdominal pain and dorsalgia occurred more frequently in malignant pheochromocytomas (26% versus 7%, p = 0.0014). Unusually short histories and extraadrenal localization appear to be suspicious for malignancy. The "typical" clinical signs and symptoms occur more frequently in patients with benign tumours and can therefore be regarded as typical signs of benign pheochromocytomas. Malignant pheochromocytomas are more difficult to treat owing to local inoperability arising from either organ invasion or metastasis. A remission rate of up to 30% has been reported in response to radiotherapy with [1311]-meta-iodobenzylguanidine

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