Pramipexole modulates the neural network of reward anticipation

Zheng, Yuxiao; Hammer, Anke; Càmara, Estela; Münte, Thomas F.

doi:10.1002/hbm.21067

Cited by 91 publications

(61 citation statements)

References 45 publications

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“…Similarly, a decrease in the correlation between reward prediction error and BOLD response was observed in the orbitofrontal cortex and striatum in early-stage PD patients B1-2 h after administration of 1.0 mg of pramipexole (van Eimeren et al, 2009), suggesting impairment in reward circuitry. A recent functional connectivity analysis of healthy males demonstrated that pramipexole increases activity in the nucleus accumbens and weakens connectivity between this structure and the PFC during reward anticipation (Ye et al, 2011). Taken together, these data suggest that pramipexole induces abnormal activation patterns and connectivity within the neural circuitry critical to reward-based learning, an action that is likely to explain the IGT data in our BPD patients.…”

Section: Discussionsupporting

confidence: 61%

“…A purported mechanism for this effect is related to pramipexole's high selective affinity for D3 receptors, which are primarily expressed in the mesocorticolimbic DA pathway-a circuitry that is active during impulsive decision making (Madden et al, 2010). Indeed, several studies that have used pramipexole in single-dose challenge paradigms have confirmed its actions on rewardrelated neural networks, primarily at low doses and in healthy individuals (Riba et al, 2008;Ye et al, 2011). Low doses of pramipexole (eg, 0.25-0.5 mg) are thought to influence reward via a paradoxical effect related to activation of the presynaptic D2 autoreceptor, resulting in a blockade of phasic DA release and a blunted response to rewarding stimuli (Riba et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Dopaminergic Influences on Emotional Decision Making in Euthymic Bipolar Patients

Burdick

Braga

Gopin

et al. 2013

Neuropsychopharmacol

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We recently reported that the D2/D3 agonist pramipexole may have pro-cognitive effects in euthymic patients with bipolar disorder (BPD); however, the emergence of impulse-control disorders has been documented in Parkinson's disease (PD) after pramipexole treatment. Performance on reward-based tasks is altered in healthy subjects after a single dose of pramipexole, but its potential to induce abnormalities in BPD patients is unknown. We assessed reward-dependent decision making in euthymic BPD patients pre-and post 8 weeks of treatment with pramipexole or placebo by using the Iowa Gambling Task (IGT). The IGT requires subjects to choose among four card decks (two risky and two conservative) and is designed to promote learning to make advantageous (conservative) choices over time. Thirty-four BPD patients completed both assessments (18 placebo and 16 pramipexole). Baseline performance did not differ by treatment group (F ¼ 0.63; p ¼ 0.64); however, at week 8, BPD patients on pramipexole demonstrated a significantly greater tendency to make increasingly high-risk, high-reward choices across the five blocks, whereas the placebo group's pattern was similar to that reported in healthy individuals (treatment Â time Â block interaction, po0.05). Analyses of choice strategy using the expectancy valence model revealed that after 8 weeks on pramipexole, BPD patients attended more readily to feedback related to gains than to losses, which could explain the impaired learning. There were no significant changes in mood symptoms over the 8 weeks, and no increased propensity toward manic-like behaviors were reported. Our results suggest that the enhancement of dopaminergic activity influences risk-associated decision-making performance in euthymic BPD. The clinical implications remain unknown.

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Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Dopaminergic Influences on Emotional Decision Making in Euthymic Bipolar Patients

Burdick

Braga

Gopin

et al. 2013

Neuropsychopharmacol

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“…Indeed, the ventral striatum is implicated in general motivational salience, together with other key structures, including the midbrain dopaminergic centers and the prefrontal cortex . Dopamine agonists may modulate the activation of this complex network (Ishibashi et al, 2011;Ye et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Dopamine Agonists on Adaptive and Aberrant Salience in Parkinson's Disease

Nagy

Levy-Gigi

Somlai

et al. 2011

Neuropsychopharmacol

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Clinical evidence suggests that after initiation of dopaminergic medications some patients with Parkinson's disease (PD) develop psychotic symptoms, such as hallucinations and delusions. Here, we tested the hypothesis that the neurocognitive basis of this phenomenon can be defined as the formation of arbitrary and illusory associations between conditioned stimuli and reward signals, called aberrant salience. Young, never-medicated PD patients and matched controls were assessed on a speeded reaction time task in which the probe stimulus was preceded by conditioned stimuli that could signal monetary reward by color or shape. The patients and controls were re-evaluated after 12 weeks during which the patients received a dopamine agonist (pramipexole or ropinirole). Results indicated that dopamine agonists increased both adaptive and aberrant salience in PD patients, that is, formation of real and illusory associations between conditioned stimuli and reward, respectively. This effect was present when associations were assessed by means of faster responding after conditioned stimuli signaling reward (implicit salience) and overt rating of stimulus-reward links (explicit salience). However, unusual feelings and experiences, which are subclinical manifestations of psychotic-like symptoms, were specifically related to irrelevant and illusory stimulus-reward associations (aberrant salience) in PD patients receiving dopamine agonists. The learning of relevant and real stimulus-reward associations (adaptive salience) was not related to unusual experiences. These results suggest that dopamine agonists may increase psychotic-like experiences in young patients with PD, possibly by facilitating dopaminergic transmission in the ventral striatum, which results in aberrant associations between conditioned stimuli and reward. Neuropsychopharmacology (2012) 37, 950-958;

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“…Furthermore, when a person faces a possible monetary gain, DA is considered to be a molecule that increases the emotional response through the bilateral overactivation of the nucleus accumbens (Ye, Hammer, Camara, & Munte, 2011). In light of these findings, there is reason to believe that patients with PD who gamble on slot machines and while taking a DA may be more sensitive to intermittent reinforcement provoked by these machines.…”

Section: Discussionmentioning

confidence: 99%

Gambling Habits of People With Parkinson’s Disease: An Exploratory Study

Nadeau¹,

Giroux²,

Simard³

et al. 2017

JGI

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The development of pathological gambling (PG) among people with Parkinson's disease (PD) is increasingly reported. The intake of dopamine agonists is most often associated with the emergence of this addiction. Although it is known that gambling habits contribute to the onset of gambling problems in the general population, these habits have not yet been studied in individuals with PD. Thus, this study aimed to explore gambling habits in people with PD. Twenty-five individuals with PD and 8 caregivers participated. Thirteen gamblers took part in a semi-structured interview regarding their gambling habits and the presence of a gambling problem and other impulse-control disorders. The results show that gamblers mainly play lotteries and slot machines. Most gamble for pleasure, but some reported wanting to win money to finance a cure for their PD. None of the gamblers involved a caregiver in their gambling activities and no gambler currently presented a gambling problem. However, 2 at-risk gamblers reported having developed a gambling problem in the past. This study sheds light on factors that may contribute to the development of PG among patients with PD, namely, the emergence of new reasons for gambling after a PD diagnosis, erroneous beliefs about gambling, and discretion about gambling habits. Prevention strategies are discussed in view of these results. However, given the small sample size, further studies examining the gambling habits of people with PD are required.Keywords: Parkinson's disease, pathological gambling, gambling habits RésuméDe plus en plus, on observe le développement du jeu pathologique (JP) chez les personnes atteintes de la maladie de Parkinson (MP). La prise d'agonistes de la

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Pramipexole modulates the neural network of reward anticipation

Cited by 91 publications

References 45 publications

Dopaminergic Influences on Emotional Decision Making in Euthymic Bipolar Patients

Dopaminergic Influences on Emotional Decision Making in Euthymic Bipolar Patients

The Effect of Dopamine Agonists on Adaptive and Aberrant Salience in Parkinson's Disease

Gambling Habits of People With Parkinson’s Disease: An Exploratory Study

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