Präoperative Zervixdilatation bei der Interruptio im I. Trimenon durch Sulproston

Abstract

Retrospectively we have compared the efficacy, the immediate complications, and the side effects during termination of 727 first trimester pregnancies with and without preoperative cervical dilatation by sulprostone. All these patients had been admitted to the Frauenklinik der Medizinischen Hochschule L ubeck for legal abortion; 365 of them got a single intramuscular injection of 500 micrograms sulprostone 8-10 hours prior to vacuum aspiration (failure 4% Hegar less than 6); 81 patients got a single intramuscular-intracervical injection of 25 micrograms sulprostone 8-10 hours prior to vacuum aspiration (failure 16% Hegar less than 6); in 281 patients evacuation of the uterus was carried out in dilating the cervix mechanically. This route without preoperative dilatation by the prostaglandin analogue sulprostone gave the highest rate of complications. Only in regard to a complete evacuation of the uterus a single intramuscular-intracervical injection of sulprostone resulted in a diminution of the complications. However, a single intramuscular injection of 500 micrograms sulprostone prior to vacuum aspiration offered a practical, effective and relatively side-effect free method of cervical dilatation.

Tonometrische und tokographische Untersuchungen zum zervixselektiven Priming mit Sulproston-Gel beim Schwangerschaftsabbruch im I. Trimenon

“…Zum präoperativen Zervixpriming im I. Trimenon wurde Sulproston bisher fast ausschliesslich intramural-zervikal [Wiechell, 1979[Wiechell, , 1981Jerve und Fylling, 1983] sowie intramuskulär [Heinzl et al, 1982;Schulz et al, 1985] appliziert. Die Akzeptanz dieser Methoden wird allerdings durch eine hohe Rate kontraktionsbedingter Unterbauchschmerzen und gastro intestinaler Nebenwirkungen erheblich eingeschränkt.…”