In the context of digital revolution and health crises (COVID-19), the major challenge for human resource managers is to find paths and strategies to reconcile HRM (Human Resources Management) practices with the new business environments. The new challenge consists, therefore, to reduce the gap which exists between ancient management practices and new strategies related to turbulent environments, and requires the adaptation of human resources to the significant and rapid technological changes, through the continuous training of workers. The companies also have to pay attention to the improvement of workers well-being, and working environment. This study aims to explore and analyze the relationship between human resources management and enterprise economic performance via the mediation of employees’ conditions and motivation. A statistical approach seems product such analysis. A questionnaire have been used to collect data from both leaders and employees across 53 enterprises in Bamako and its peripheries, Mali. Hence, we used the 5-point Likert attitude scale. Utilizing 733 recovered questionnaires, the study employed the regression analysis method to test direct effects. However, the Sobel test was applied to test indirect effects. The results of this study indicated that in a poor business environment, employees remuneration and their career plan affect positively and significantly enterprise economic performance. But, surprisingly, employee’ conditions and motivation don’t affect directly firm performance. Additionally, they also shown that workers conditions and motivation mediate the relationship between human resources management and company organizational performance. The sample was drawn using the probabilistic technique. It have been composed by employees and managers. These conclusions align partially with the perspectives of needs and motivation theories, unveiling the diverse effects of human resources management on firm economic performance and underscoring the necessity for long-term investments in workers well-being improvement. Consequently, the study enriches the literature on human resources management practices, and contributes to the enrichment of positive psychology, needs and motivation theories and reminds us to think carefully about the value of working environment improvement and workers well-being enhancement.