Prävalenz von Antikörpern gegen Borrelia burgdorferi, Anaplasma phagocytophilum und bestimmte Leptospira-interrogans-Serovare bei Berner Sennenhunden

Preyß-Jägeler, C.; Müller, Elisabeth; Straubinger, Reinhard K.; Hartmann, Katrin

doi:10.15654/tpk-140962

Cited by 11 publications

(8 citation statements)

References 35 publications

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“…In Europe, Anaplasma spp. seroprevalence has been reported in almost all countries with rates ranging from 1.1 to 56.5% ( 143 , 148 , 150 , 183 , 190 ). The detection of A. phagocytophilum DNA has also been reported mostly from central and northern countries ( Table 1 ) with prevalence rates up to 14.2% ( 174 ).…”

Section: Distribution and Prevalence Of Anaplasma Phagocytophilummentioning

confidence: 99%

Epidemiological and Clinicopathological Features of Anaplasma phagocytophilum Infection in Dogs: A Systematic Review

et al. 2021

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Anaplasma phagocytophilum is a worldwide emerging zoonotic tick-borne pathogen transmitted by Ixodid ticks and naturally maintained in complex and incompletely assessed enzootic cycles. Several studies have demonstrated an extensive genetic variability with variable host tropisms and pathogenicity. However, the relationship between genetic diversity and modified pathogenicity is not yet understood. Because of their proximity to humans, dogs are potential sentinels for the transmission of vector-borne pathogens. Furthermore, the strong molecular similarity between human and canine isolates of A. phagocytophilum in Europe and the USA and the positive association in the distribution of human and canine cases in the USA emphasizes the epidemiological role of dogs. Anaplasma phagocytophilum infects and survives within neutrophils by disregulating neutrophil functions and evading specific immune responses. Moreover, the complex interaction between the bacterium and the infected host immune system contribute to induce inflammatory injuries. Canine granulocytic anaplasmosis is an acute febrile illness characterized by lethargy, inappetence, weight loss and musculoskeletal pain. Hematological and biochemistry profile modifications associated with this disease are unspecific and include thrombocytopenia, anemia, morulae within neutrophils and increased liver enzymes activity. Coinfections with other tick-borne pathogens (TBPs) may occur, especially with Borrelia burgdorferi, complicating the clinical presentation, diagnosis and response to treatment. Although clinical studies have been published in dogs, it remains unclear if several clinical signs and clinicopathological abnormalities can be related to this infection.

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Section: Distribution and Prevalence Of Anaplasma Phagocytophilummentioning

confidence: 99%

Epidemiological and Clinicopathological Features of Anaplasma phagocytophilum Infection in Dogs: A Systematic Review

et al. 2021

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“…This dog breed seems to have a predisposition for B. burgdorferi s.l. infection, as demonstrated by several studies (97)(98)(99), although the reasons for this predisposition are unknown (58). As reported above, a significant effect of the utilized diagnostic test on the seroprevalence in dogs was found (section Tick-Borne Encephalitis Virus, Supplementary Figure 1), with lower rates determined by the most recently developed test, a C6-based rapid ELISA, than by conventional ELISA or IFAT (57).…”

Section: Dogs and Catsmentioning

confidence: 68%

Zoonotic Tick-Borne Pathogens in Temperate and Cold Regions of Europe—A Review on the Prevalence in Domestic Animals

et al. 2020

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Ticks transmit a variety of pathogens affecting both human and animal health. In temperate and cold regions of Europe (Western, Central, Eastern, and Northern Europe), the most relevant zoonotic tick-borne pathogens are tick-borne encephalitis virus (TBEV), Borrelia spp. and Anaplasma phagocytophilum. More rarely, Rickettsia spp., Neoehrlichia mikurensis, and zoonotic Babesia spp. are identified as a cause of human disease. Domestic animals may also be clinically affected by these pathogens, and, furthermore, can be regarded as sentinel hosts for their occurrence in a certain area, or even play a role as reservoirs or amplifying hosts. For example, viraemic ruminants may transmit TBEV to humans via raw milk products. This review summarizes the role of domestic animals, including ruminants, horses, dogs, and cats, in the ecology of TBEV, Borrelia spp., A. phagocytophilum, Rickettsia spp., N. mikurensis, and zoonotic Babesia species. It gives an overview on the (sero-)prevalence of these infectious agents in domestic animals in temperate/cold regions of Europe, based on 148 individual prevalence studies. Meta-analyses of seroprevalence in asymptomatic animals estimated an overall seroprevalence of 2.7% for TBEV, 12.9% for Borrelia burgdorferi sensu lato (s.l.), 16.2% for A. phagocytophilum and 7.4% for Babesia divergens, with a high level of heterogeneity. Subgroup analyses with regard to animal species, diagnostic test, geographical region and decade of sampling were mostly non-significant, with the exception of significantly lower B. burgdorferi s.l. seroprevalences in dogs than in horses and cattle. More surveillance studies employing highly sensitive and specific test methods and including hitherto non-investigated regions are needed to determine if and how global changes in terms of climate, land use, agricultural practices and human behavior impact the frequency of zoonotic tick-borne pathogens in domestic animals.

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“…The clinical data and laboratory test results were derived from data collected for another study with prospectively enrolled dogs [ 15 ]. Apart from the published results, additional data was collected and additional laboratory tests were performed for the study that have not yet been analyzed.…”

Section: Methodsmentioning

confidence: 99%

“…Several studies revealed a significantly higher prevalence of antibodies to B. burgdorferi sensu lato and to Anaplasma (A.) phagocytophilum in BMDs than in control dogs indicating a higher infection prevalence [ 14 , 15 ]. Chronic persistent infections, such as with B. burgdorferi sensu lato, Ehrlichia spp., and Anaplasma spp.…”

Section: Introductionmentioning

confidence: 99%

Changes in renal parameters and their association with subclinical vector-borne infections in Bernese Mountain dogs

2020

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Background An increased risk for glomerulonephritis and a higher prevalence of antibodies to Borrelia (B.) burgdorferi sensu lato have been reported in Bernese mountain dogs (BMDs). The aim of the study was to determine the prevalence of laboratory abnormalities suggestive of kidney disease in clinically healthy BMDs compared to a control population and to investigate if there is a correlation with the occurrence of antibodies to B. burgdorferi sensu lato, Ehrlichia canis, and Anaplasma (A.) spp. and with the occurrence of Dirofilaria (D.) immitis antigen. A total of 197 BMDs and 57 control dogs were included in the study. Laboratory evidence of kidney disease was defined as renal azotemia and/or proteinuria with a urine protein creatinine ration of more than 0.5 in an inactive urine sediment. A SNAP®4Dx® ELISA (IDEXX, Laboratories, Inc., Westbrook, ME, USA) was used to detect antibodies to B. burgdorferi sensu lato, E. canis and Anaplasma spp. and antigen of D. immitis. Results Laboratory evidence of kidney disease was significantly more common in BMDs than in control dogs (17.8% versus 1.8%) (p = 0.005). The proportion of BMDs with anti-B. burgdorferi sensu latu antibodies and anti-A. phagocytophilum antibodies was significantly higher in BMDs (p < 0.001). However, an association between these findings could not be identified. Conclusion BMDs are more often affected by kidney disease and have a higher prevalence of antibodies to bacterial pathogens transmitted by Ixodes ticks than control dogs. However, a causal relationship between these two variables could not be established due to a lack of association between these two findings.

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Prävalenz von Antikörpern gegen Borrelia burgdorferi, Anaplasma phagocytophilum und bestimmte Leptospira-interrogans-Serovare bei Berner Sennenhunden

Cited by 11 publications

References 35 publications

Epidemiological and Clinicopathological Features of Anaplasma phagocytophilum Infection in Dogs: A Systematic Review

Epidemiological and Clinicopathological Features of Anaplasma phagocytophilum Infection in Dogs: A Systematic Review

Zoonotic Tick-Borne Pathogens in Temperate and Cold Regions of Europe—A Review on the Prevalence in Domestic Animals

Changes in renal parameters and their association with subclinical vector-borne infections in Bernese Mountain dogs

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