Pravastatin Inhibits Arrhythmias Induced by Coronary Artery Ischemia in Anesthetized Rats

Chen, Jianguang; Shen, Hua; Nagasawa, Yoshinori; Mitsui, Kazuhiro; Tsurugi, Kunio; Hashimoto, Keitaro

doi:10.1254/jphs.fp0061235

Cited by 19 publications

(16 citation statements)

References 38 publications

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“…MPO activity was measured in mouse tongues using a modification of the method of Chen et al (14). After mice had been killed by cervical dislocation 12 days after irradiation, tongue samples (n ¼ 10 per group) were removed and stored at À70 C until required for assay.…”

Section: Determination Of Myeloperoxidase (Mpo) Activitymentioning

confidence: 99%

Evaluation of edaravone against radiation-induced oral mucositis in mice

Nakajima

Watanabe

Kiyoi

et al. 2015

Journal of Pharmacological Sciences

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Oral mucositis induced by radiotherapy for cancers of the head and neck reduce the quality of life of patients. However, effective therapeutic agents are lacking. Symptomatic treatment involves local anesthesia and analgesia. We focused on the antioxidant effects of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one; Radicut(®)). Oral mucositis was induced on the tongue tips of mice using a single dose of X-rays (20 Gy). To evaluate the protective effect of edaravone (30 and 300 mg/kg), administration was carried out 30 min before irradiation. Survival, oral mucositis score, myeloperoxidase activity, and levels of 2-Thiobarbituric acid reactive substances were measured, and all were improved compared with those of control mice. A significant difference was not found in terms of survival due to edaravone. Histopathologic findings also highlighted the beneficial features of edaravone. Edaravone reduced the production of reactive oxygen species. These findings suggest that the protective effect of edaravone against radiation-induced oral mucositis is through an antioxidant effect.

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Section: Determination Of Myeloperoxidase (Mpo) Activitymentioning

confidence: 99%

Evaluation of edaravone against radiation-induced oral mucositis in mice

Nakajima

Watanabe

Kiyoi

et al. 2015

Journal of Pharmacological Sciences

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“…MPO activity, a marker for neutrophils in inflamed tissue, was also measured in hamster cheek pouches using a modification of the method of Chen et al (26).…”

Section: Determination Of Myeloperoxidase (Mpo) Activitymentioning

confidence: 99%

Oral Mucosal Adhesive Films Containing Royal Jelly Accelerate Recovery From 5-Fluorouracil^|^ndash;Induced Oral Mucositis

et al. 2013

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Abstract. Oral mucositis induced by chemotherapy or radiotherapy has an impact upon qualityof-life, is dose-limiting for chemotherapy, and causes considerable morbidity. We evaluated the effect of royal jelly (RJ) on 5-fluorouracil (5-FU)-induced oral mucositis in hamsters. Oral mucositis was induced in hamsters through a combination of 5-FU treatment and mild abrasion of the cheek pouch. RJ was contained in chitosan-sodium alginate film (RJ film). Films were attached to the oral mucosa and the healing process examined by measuring the area of mucositis, myeloperoxidase (MPO) activity, microscopic aspects, and RT-PCR for detection of pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-1β). Furthermore, we evaluated the radicalscavenging activity of RJ and generation of keratinocyte growth factor from human periodontal ligament fibroblasts. RJ films (10%, 30%) significantly improved recovery from 5-FU-induced damage, reduced MPO activity and the production of pro-inflammatory cytokines. Additionally, RJ showed radical-scavenging activity. These data suggest that topical application of films that contain RJ had a healing effect on the severe oral mucositis induced by 5-FU and that the effect was caused by the anti-inflammatory or anti-oxidative activities of RJ.

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“…In fact, a previous report showed decreased neutrophil infiltration as a mechanism of the antiarrhythmic effect of chronic oral administration of statins. 22 We also tried rosuvastatin in a Langendorff experiment using the same protocol with pre-ischemic pravastatin treatment and there was a similar effect to that of pravastatin ( Figure S3). These results indicate that the antiarrhythmic effects observed in the present study are not specific for pravastatin and are applicable to other statins.…”

Section: Discussionmentioning

confidence: 94%

“…22 Clinical reports showed that long-term treatment with statins is associated with a reduction in life-threatening ventricular arrhythmias in patients with coronary artery disease 23 or after reperfusion therapy for AMI. 24 In the present study, we showed that oral intake of pravastatin for 7 days conferred antiarrhythmic effects in anesthetized rats subjected to local I/R by LAD occlusion.…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective Effects of Pravastatin Against Lethal Ventricular Arrhythmias Induced by Reperfusion in the Rat Heart

Thuc

Teshima

Takahashi

et al. 2011

Circ J

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Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp eperfusion therapy by primary percutaneous coronary intervention or thrombolysis is the most effective strategy to reduce mortality and improve the clinical outcome in acute myocardial infarction (AMI). However, reperfusion itself is associated with a risk of lethal ventricular arrhythmias. In fact, reperfusion-induced arrhythmias were identified in 30% of patients with successful reperfusion by thrombolysis. 1 Furthermore, in the majority of cases, successful restoration of coronary flow by primary angioplasty is accompanied by reperfusion-induced arrhythmias, including bradyarrhythmias, ventricular premature contractions (VPC), ventricular tachycardia (VT) and ventricular fibrillation (VF). 2 VT and VF by spontaneous recanalization are especially critical and underlie many cases of sudden cardiac death before hospital arrival. In a previous study of 12 patients who developed VF before the arrival of the ambulance, only one patient was discharged alive. 3 The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are attracting much attention because of their putative pleiotropic effects. We have reported that administration of atorvastatin in the early phase of an AMI improves cardiac function and attenuates B-type natriuretic peptide increase, and these effects were assumed to be independent of the drug's lipid-lowering effect. 4 Consistently, other reports have shown that early statin treatment for AMI patients decreases the risk of congestive heart failure and long-term mortality. 5,6 Several large clinical trials have also shown that statins reduce sudden cardiac death in patients with coronary

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Pravastatin Inhibits Arrhythmias Induced by Coronary Artery Ischemia in Anesthetized Rats

Cited by 19 publications

References 38 publications

Evaluation of edaravone against radiation-induced oral mucositis in mice

Evaluation of edaravone against radiation-induced oral mucositis in mice

Oral Mucosal Adhesive Films Containing Royal Jelly Accelerate Recovery From 5-Fluorouracil^|^ndash;Induced Oral Mucositis

Cardioprotective Effects of Pravastatin Against Lethal Ventricular Arrhythmias Induced by Reperfusion in the Rat Heart

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