Pravastatin regulates host foreign-body reaction to polyetheretherketone implants via miR-29ab1-mediated SLIT3 upregulation

Liao, Yun; Ouyang, Liping; Ci, Lei; Chen, Baohui; Lv, Dan; Li, Qin; Sun, Yingxiao; Fei, Jian; Bao, Shisan; Liu, Xuanyong; Li, Ling

doi:10.1016/j.biomaterials.2019.02.027

Cited by 24 publications

(23 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…loaded pravastatin (Pra) onto a 3D sulfonated polyetheretherketone (PEEK) and demonstrated that Pra promoted angiogenesis and mitigated the FBR via miR‐29 dependent SLIT3 upregulation. [ 190 ] Grainger et al. reported that with the sustained release of the tyrosine kinase inhibitor, masitinib, the capsule thicknesses of the sensor implant was significantly reduced during the 28‐day implantation.…”

Section: Conventional Strategies To Migrate the Fbrmentioning

confidence: 99%

Dealing with the Foreign‐Body Response to Implanted Biomaterials: Strategies and Applications of New Materials

Zhang

Chen

Shi

et al. 2020

Adv Funct Materials

176

139

View full text Add to dashboard Cite

Foreign‐body response caused by implanted biomaterials seriously impedes the function of implants and is a major obstacle to the development of implantable biomaterials and medical devices. Recent advances in implantable biomaterials and medical devices have provided strategies to resist the foreign‐body response. In this review, the mechanism of the foreign‐body response and conventional strategies to mitigate foreign‐body response is briefly introduced. Then, three types of promising foreign‐body response resisting materials are focused and the advantages, characteristics, and applications of each material are discussed. Finally, prospects are put forward for future development of foreign‐body response resisting materials and current challenges that require in‐depth study.

show abstract

Section: Conventional Strategies To Migrate the Fbrmentioning

confidence: 99%

Dealing with the Foreign‐Body Response to Implanted Biomaterials: Strategies and Applications of New Materials

Zhang

Chen

Shi

et al. 2020

Adv Funct Materials

176

139

View full text Add to dashboard Cite

show abstract

“…A miR-29a/b 1 knockout mouse line was established using CRISPR/Cas9 gene editing technology and was supplied by Shanghai Center for Model Organisms (SMOC) (17). miR-29a/ b 1 −/− homozygous animals and their wild-type littermates were obtained by mating corresponding heterozygotes with each other.…”

Section: Generation Of Mir-29a/b 1 Knockout Micementioning

confidence: 99%

miR-29a/b1 Regulates the Luteinizing Hormone Secretion and Affects Mouse Ovulation

Guo

Shi

et al. 2021

Front. Endocrinol.

Self Cite

View full text Add to dashboard Cite

miR-29a/b1 was reportedly involved in the regulation of the reproductive function in female mice, but the underlying molecular mechanisms are not clear. In this study, female mice lacking miR-29a/b1 showed a delay in vaginal opening, irregular estrous cycles, ovulation disorder and subfertility. The level of luteinizing hormone (LH) was significantly lower in plasma but higher in pituitary of mutant mice. However, egg development was normal in mutant mice and the ovulation disorder could be rescued by the superovulation treatment. These results suggested that the LH secretion was impaired in mutant mice. Further studies showed that deficiency of miR-29a/b1 in mice resulted in an abnormal expression of a number of proteins involved in vesicular transport and exocytosis in the pituitary, indicating the mutant mice had insufficient LH secretion. However, the detailed mechanism needs more research.

show abstract

“…The classical foreign body response may now be seen as a process regulated by specific biochemical pathways, the nature of which will depend on the local circumstances. Liao et al have shown that the response to the widely used implant material polyetheretherketone is controlled by the miR-29ab1-mediated SLT3 upregulation, and that this may be influenced by the local delivery of pravastatin (Liao et al, 2014). With degradable magnesium alloys, the stimulation of osteogenesis may be achieved via the upregulation of transcription factors in the ERK signaling pathway through the effects of released metal ions such as calcium and strontium (Li et al, 2016); the overall effects of magnesium on the fate of mesenchymal stem cells mediated via different pathways has been reviewed by Luthringer and Willumeit-Romer (2016).…”

Section: Control Of Biocompatibility Through Modulation Of Biocompatimentioning

confidence: 99%

Specifications for Innovative, Enabling Biomaterials Based on the Principles of Biocompatibility Mechanisms

Williams

2019

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

In any engineering discipline, whenever products are designed, manufactured and ultimately utilized for the benefits of society, a series of specifications for the product are defined, and maybe refined, in order that they perform as effectively as possible, with due attention being paid to the safety, and economic aspects. These specifications are established with respect to all of the relevant properties, including those determined by mechanical, physical, chemical, manufacturing and environmental conditions, and the resulting design and materials selection reflects the optimal balance. In areas of medical technology, these specifications should be based on both functionality, which determines whether a device can actually perform as intended, and biocompatibility, which determines how the device interacts, both acutely and chronically, with the body. Unfortunately, whilst so much progress has been made with the development of superior functionality for the treatment and diagnosis of so many disease states, this is not the same for biocompatibility, where the single most-important currently adopted specification is that the device should do no harm, which falls far short of the ideal requirement. This paper addresses the profound need for biomaterials specifications to be based on the mechanisms of biocompatibility.

show abstract

Pravastatin regulates host foreign-body reaction to polyetheretherketone implants via miR-29ab1-mediated SLIT3 upregulation

Cited by 24 publications

References 48 publications

Dealing with the Foreign‐Body Response to Implanted Biomaterials: Strategies and Applications of New Materials

Dealing with the Foreign‐Body Response to Implanted Biomaterials: Strategies and Applications of New Materials

miR-29a/b1 Regulates the Luteinizing Hormone Secretion and Affects Mouse Ovulation

Specifications for Innovative, Enabling Biomaterials Based on the Principles of Biocompatibility Mechanisms

Contact Info

Product

Resources

About