Pravastatin suppresses the increase in matrix metalloproteinase-2 levels after acute myocardial infarction

Serum lipids and cardiac function correlate with nitrotyrosine and MMP activity in coronary artery disease patients

“…Furthermore, we have found here that LVEF correlated negatively with MMP-9 activity, however, there was no correlation with MMP-2 activity. This is partly in accordance with previous findings that both MMP-2 and MMP-9 protein levels correlate with LVEF or left ventricular end-diastolic volume index in cardiac patients with acute myocardial infarction or heart failure [34][35][36]. We have also examined here the correlation of serum cholesterol and triglyceride levels with LVEF, however, we did not observe any significant correlation among these data.…”

Matrix Metalloproteinases: Drug Targets for Myocardial Infarction

“…Statins, however, can also trigger the upregulation of macrophage elastase (MMP-12) [134]. Pravastatin reduces serum soluble CD40L, C-reactive protein, MMP-2, and MMP-9 levels in post-MI patients [135][136][137]. Turner et al demonstrated that simvastatin suppresses TNF--induced invasion of human cardiac myofibroblasts by both MMP-9-dependent and -independent mechanisms, indicating that statins likely have effects on MMPs through multiple pathways [138].…”

Peroxynitrite - matrix metalloproteinase and erythropoietin receptor signaling pathways in ischemic heart disease

“…Furthermore, we have found here that LVEF correlated negatively with MMP-9 activity; however, there was no correlation with MMP-2 activity. This is partly in accordance with previous findings showing that MMP-2 and MMP-9 protein levels correlate with LVEF or left ventricular end diastolic volume index in cardiac patients with acute myocardial infarction or heart failure [81][82][83]. We have also examined here the correlation of serum cholesterol and triglyceride levels with LVEF, however, we did not observe any significant correlation among these data.…”

“…Other authors have also reported a reduction in plasma MMP-2 and/or MMP-9 protein levels after statin treatment of cardiac patients; however, in these studies, only MMP protein levels were measured [81][82][83]87]. …”