Prävention von CMV-Infektionen bei Frühgeborenen durch Muttermilch

Jugendheilkunde, Ernährungskommission der Österreichischen Gesellschaft für Kinder und; Zwiauer, Karl

doi:10.1007/s00112-009-2019-5

Cited by 11 publications

(5 citation statements)

References 11 publications

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“…Decisions about breastfeeding of very low birth weight infants by mothers known to be HCMV-seropositive should be made with caution, weighing the potential benefits of human milk versus the risk of HCMV transmission. The Committee for Nutrition of the Austrian Society of Paediatrics and Adolescent Medicine [16] recommends determining the HCMV serostatus of every mother and, in the case of HCMV-IgG-positivity, the colostrum has to be abandoned and breast milk has to be pasteurized before being fed. This procedure is suggested for the infant up to the corrected gestational age of 35 weeks.…”

Section: Discussionmentioning

confidence: 99%

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Transmission of cytomegalovirus via breast milk to the prematurely born infant: a systematic review

Kurath

Halwachs‐Baumann

Müller

et al. 2010

Clinical Microbiology and Infection

119

123

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To analyse current data on transmission of human cytomegalovirus (HCMV) via breast milk with subsequent symptomatic HCMV infection of the preterm infant and to report on long-term follow-up, a systematic literature review was performed using EMBASE, MEDLINE and CINAHL (January 1966 to December 2008) Studies were included for analysis if congenital HCMV infection was excluded and transmission via breast milk was either confirmed or strongly suspected. Twenty-six studies were included for analysis. Maternal HCMV-IgG-positivity was reported to be in the range 51.6-100% (median 81.6%), HCMV-IgG detection in breast milk in the range 67-97.2% (median 80%) and HCMV-positivity of the infants in the range 5.7-58.6%. Symptomatic HCMV disease occurred in 0-34.5% (median 3.7%) and severe sepsis-like syndrome in 0-13.8% (median 0.7%). Data on long-term outcome of preterm infants with symptomatic HCMV infection revealed a low risk for mild neurological and cognitive sequelae, without hearing impairment. Recommendations for high-risk preterm infants diverged markedly. The current data report low rates of symptomatic disease after transmission of HCMV via breast milk to the preterm infant without evidence of certain long-term sequelae. The results of our review do not support a general approach, either by avoidance or pasteurization of breast milk, in high-risk preterm infants.

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Section: Discussionmentioning

confidence: 99%

“…Although freezing procedures do not completely eliminate the virus, these methods are found to be less harmful to immunological factors contained in breast milk. Thus, different recommendations for breastfeeding the premature born infant have been reported [16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Transmission of cytomegalovirus via breast milk to the prematurely born infant: a systematic review

Kurath

Halwachs‐Baumann

Müller

et al. 2010

Clinical Microbiology and Infection

119

123

View full text Add to dashboard Cite

show abstract

“…The ongoing debate on whether and how to inactivate HCMV in breast milk (Hamprecht et al, 2005) resulted in a consensus paper of the Austrian Society of Pediatrics that recommended Holder pasteurisation of every seropositive milk sample up to the end of 34 weeks of corrected age of the preterm infant (Zwiauer et al, 2003). The French Society for the safety of nutrition proposes not to feed raw breast milk to preterm infants born before 32 weeks gestational age or below a birth weight of 1500 g (Afssa, 2005).…”

Section: Clinical Studies On Hcmv Transmission By Breastfeedingmentioning

confidence: 99%

Cytomegalovirus transmission to preterm infants during lactation

Hamprecht

Maschmann

Jahn

et al. 2008

Journal of Clinical Virology

154

114

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“…The median total impairment standard score between infected children and noninfected children was 8 points and 9 points (P = .661), respectively, and was in the normal range. (22) .393 7 (17) 37 (22) .528 Cranial ultrasonography findings IVH (%) Grade I, n (%) 5 (11) 29 (14) .576 5 (12) 20 (12) .919 Grade II, n (%) 6 (13) 27 (13) .996 4 (10) 24 (14) .475 LSV at TEA, n (%) 20 (36) 49 (17) .001 15 (37) 34 (20) .021 Germinolytic cysts at TEA, n (%) 5 (15) 12 (13) .729 5 (12) 25 (15) .699…”

Section: Mabc-ii At 6 Years Of Agementioning

confidence: 99%

“…13 -15 Because of the uncertainty regarding the short-and long-term consequences of a pCMV infection, fresh, untreated breast milk is not always given to VLBW infants. [16][17][18] Because (untreated) breast milk is known to improve infant health, 19 it is important to study the effects of pCMV infection in a large cohort of preterm infants. Our aim in this prospective, longitudinal cohort study is to examine the consequences of a pCMV infection on neurodevelopmental outcomes, including hearing, in a cohort of preterm infants until 6 years of age.…”

mentioning

confidence: 99%