The article presents the results of the study of metabolic endogenous intoxication (MEI) indicators -molecules of average mass (MSM), anti-inflammatory cytokines IL-6, IL-8 and IL-10, and their correlation with cognitive disorders, and also investigates the dynamics of these indicators and regression of cognitive disorders against the proposed scheme of low volume infusion detoxification therapy with hyperosmolar balanced crystalloid in the context of a 30-day period.Results and discussion.A positive therapeutic effect on the dynamics of the level of MEI markers, levels of proinflammatory cytokines and the severity of pain syndrome in patients with CP with concomitant T2DM has been proven, indicating the positive effect of including a scheme of low-volume infusion therapy in the program of complex treatment. A clear dependence of the severity of pain syndrome on the therapy course was revealed.Conclusions:1. Statistically significant increase of objective markers of endogenous intoxication in patients with chronic pancreatitis with concomitant diabetes mellitus was revealed in comparison with the same in isolated chronic pancreatitis (p<0,05).2. Strong correlations between levels of proinflammatory cytokines and severity of pain syndrome and deterioration of cognitive status in patients with CP in comorbidity with DM2 were revealed.3. We found medium strength correlations between markers of endogenous intoxication MSM and levels of IL-1, IL-6, IL-10, which allows predicting the effect of MOIT at the level of proinflammatory cytokines.4. A higher level of efficacy of application in complex therapy of exacerbation of CP in combination with T2DM 5 sessions of MOIT in comparison with the program with 3 sessions was established.
Конфлікт інтересів відсутній.Внесок автора: Земляк О.С. -ідея, аналіз літератури, дизайн дослідження, набір клінічного матеріалу, статистичний аналіз, написання статті, висновки, анотації, корекція статті.