Prazosin increases paradoxical sleep

Hilakivi, I.; Leppävuori, Antero; Putkonen, Pekka T.S.

doi:10.1016/0014-2999(80)90346-5

Cited by 35 publications

(12 citation statements)

References 6 publications

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“…This result corresponds quite well with the study of Pellejero [16] but is at variance with the significant prolongation of PS observed after i.p. administration of 0.5 and 1 mg/kg prazosin in rats and cats [7,15]. This discrep ancy could not be explained by a different time schedule of application or recording time because we have re ceived the same results in the 8-hour as well as in the 48-hour study.…”

Section: Discussionsupporting

confidence: 64%

Effects of the Selective α<sub>1</sub>-Adrenoceptor Blocker Prazosin on EEG Sleep and Waking Stages in the Rat

Kleinlogel¹

1989

Neuropsychobiology

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In order to gain a better understanding of the role of the noradrenergic system in the control of the EEG sleep-waking stages, the effects of the selective α₁-antagonist prazosin was investigated in the rat. Oral doses of prazosin (0.1–10 mg/kg) were administered that have been shown to enter the brain. EEG sleep and waking stages were recorded either during 8 h after drug administration at 8.00 in the morning or during 48 h after drug administration at 16.00 in the afternoon. It was found that prazosin at doses of 0.1–10 mg/kg shortened quiet waking. Starting at 1 mg/kg paradoxical sleep (PS) was shortened and, most interestingly, active waking and slow wave sleep (SWS) were prolonged. PS spindles and dozing were shortened after a latency of some hours during the 48-hour experiment. However, during the 8-hour experiment PS spindles were prolonged at 0.32 and 1 mg/kg. These data suggest that in the rat α₁-adrenoceptor inhibition in the brain allows the occurrence of active waking and SWS and suppresses PS.

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Section: Discussionsupporting

confidence: 64%

Effects of the Selective α<sub>1</sub>-Adrenoceptor Blocker Prazosin on EEG Sleep and Waking Stages in the Rat

Kleinlogel¹

1989

Neuropsychobiology

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“…NA has an inhibitory role in REMS regulation [89,37,72]. The a1/a2-antagonist phentolamine as well as the a1-antagonist prazosin increased REMS in cat [102,108], raising the suspicion that blocking a1 receptors might aggravate narcoleptic attacks, as has subsequently been shown [109].…”

Section: Neurochemistry Of Sleep and Wake Acetylcholinementioning

confidence: 94%

Neuroanatomy and neurochemistry of sleep

Stenberg

2007

Cell. Mol. Life Sci.

132

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Sleep is regulated by homeostatic and circadian factors, and the regulation of sleep of mammals shares many molecular properties with the rest state of submammalian species. Several brain structures take part in waking: the basal forebrain, posterior and lateral hypothalamus, and nuclei in the tegmentum and pons. Active sleep mechanisms are located to the preoptic/anterior hypothalamic area. In addition to acetylcholine and monoamines, glutamate and hypocretin/orexin are important waking factors. Gamma-aminobutyric acid and several peptide factors, including cytokines, growth hormone-releasing hormone and prolactin, are related to sleep promotion. Adenosine is an important homeostatic sleep factor acting in basal forebrain and preoptic areas through A1 and A2A receptors. Prolonged waking activates inducible nitric oxide synthase in the basal forebrain, which through energy depletion causes adenosine release and recovery sleep. Numerous genes have been found differentially displayed in waking compared with sleep, and they relate to neural transmission, synaptic plasticity, energy metabolism and stress protection. The genetic background of a few sleep disorders has been solved.

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“…Antagonism of serotonin receptors can also be associated with sedation and can increase the amount of slow-wave sleep, whereas agonist effects at the 5HT 1A receptor may cause sleep disturbance and suppress REM sleep (Leonard, 1996;Wilson et al, 2005). Inhibition of cerebral a-1 adrenergic receptors appears to have a sleep enhancing effect and a tendency to increase REM sleep (Hilakivi et al, 1980;Hilakivi and Leppavuori, 1984). Dopaminergic antagonism can lead some individuals to experience leg restlessness, which can interfere with their ability to fall asleep, or disrupt sleep owing to periodic leg movements (Farde, 1992;Hornyak et al, 2006).…”

Section: Effects Of Schizophrenia Medications On Sleep Overviewmentioning

confidence: 96%

Effects of antipsychotic medications on sleep in schizophrenia

Krystal¹,

Goforth²,

Roth

2008

International Clinical Psychopharmacology

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Schizophrenia is often accompanied by sleep problems. Evidence exists that these sleep difficulties have significant effects on individuals with this disorder. The mainstay of treatment for this condition is the administration of medications that have effects on neurotransmitter systems, which play an important role in sleep-wake function, including histamine, acetylcholine, serotonin, norepinephrine and dopamine. Little systematic attention, however, has been paid to how the sleep effects of these agents might play a role in the course of treatment, function and quality of life of schizophrenia patients. Schizophrenia medications can improve sleep problems and reverse the sleep architectural derangements that are common among patients with schizophrenia and, therefore, have the potential to improve the quality of life and functional capacity of the patient. Conversely, some sleep-wake effects of these medications can impair patient function and quality of life. In this study, we review the effects of schizophrenia medications and discuss their relevance to optimizing the clinical treatment of people with schizophrenia with regard to sleep-wake function.

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Prazosin increases paradoxical sleep

Cited by 35 publications

References 6 publications

Effects of the Selective α<sub>1</sub>-Adrenoceptor Blocker Prazosin on EEG Sleep and Waking Stages in the Rat

Effects of the Selective α<sub>1</sub>-Adrenoceptor Blocker Prazosin on EEG Sleep and Waking Stages in the Rat

Neuroanatomy and neurochemistry of sleep

Effects of antipsychotic medications on sleep in schizophrenia

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