At a time when the world faces a number of complex problems that transcend national borders and which individual states appear unable to address on their own, multilateralism ought to matter more than ever. All too often, however, attempts to encourage collaborative and effective responses to transnational problems are unable to overcome national interests, or lack the capacity to address novel challenges that defy easy resolution. Despite the urgent need for international cooperation, it is often conspicuous by its absence and it is not unreasonable to ask, does multilateralism really matter anymore? We argue that it does, if only because, there is no alternative. To illustrate multilateralism's weaknesses and potential strengths we provide a novel comparison of the Association of Southeast Asian Nations (ASEAN) and the Arctic Council, which reveals the importance of history, diplomatic styles, the significance of issue areas, and the motivations of members. The two bodies literally and metaphorically illustrate developments in the North and South, and provide a novel and revealing benchmark for measuring the success of multilateral bodies at different moments in history.