Prdm1a directly activates <i>foxd3</i> and <i>tfap2a</i> during zebrafish neural crest specification

Powell, Davalyn R.; Hernandez-Lagunas, Laura; LaMonica, Kristi; Artinger, Kristin

doi:10.1242/dev.096164

Cited by 51 publications

(49 citation statements)

References 66 publications

(90 reference statements)

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“…The importance of Msx1, Pax7 and Zic1 in neural crest formation is clear, but other genes expressed in the neural plate border, such as Myb, Myc and Prdm1a (Bellmeyer et al, 2003;Betancur et al, 2010b;Powell et al, 2013), have also been implicated in neural crest specification. Furthermore, signaling input seems to be important for the expression of neural crest specifier genes.…”

Section: Induction and Formation Of The Neural Plate Bordermentioning

confidence: 99%

Establishing neural crest identity: a gene regulatory recipe

2015

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The neural crest is a stem/progenitor cell population that contributes to a wide variety of derivatives, including sensory and autonomic ganglia, cartilage and bone of the face and pigment cells of the skin. Unique to vertebrate embryos, it has served as an excellent model system for the study of cell behavior and identity owing to its multipotency, motility and ability to form a broad array of cell types. Neural crest development is thought to be controlled by a suite of transcriptional and epigenetic inputs arranged hierarchically in a gene regulatory network. Here, we examine neural crest development from a gene regulatory perspective and discuss how the underlying genetic circuitry results in the features that define this unique cell population.

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Section: Induction and Formation Of The Neural Plate Bordermentioning

confidence: 99%

Establishing neural crest identity: a gene regulatory recipe

2015

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“…During embryogenesis, a series of transcriptional factors including ZIC1, PAX3, TPAP2a, Notch and PRDM1A initiate the crest developmental pathway after the neural tube forms (16, 17). This distinguishes early neural crest cells from primitive neuroectoderm.…”

Section: Molecular Pathogenesis Of Neuroblastoma – a Tumor Of The Neumentioning

confidence: 99%

Neuroblastoma: Molecular Pathogenesis and Therapy

2015

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Neuroblastoma is a developmental tumor of young children arising from the embryonic sympathoadrenal lineage of the neural crest. Currently neuroblastoma is the primary cause of death from pediatric cancer for children between the age of 1 and 5 years and accounts for approximately 13% of all pediatric cancer mortality. Its clinical impact and its unique biology have made this aggressive malignancy the focus of a large concerted translational research effort. New insights into tumor biology are driving the development of new classification schemas; novel targeted therapeutic approaches include small molecule inhibitors, epigenetic, non-coding RNA, and cell-based immunologic therapies. Recent insights regarding the pathogenesis and biology of neuroblastoma will be placed in context with the current understanding of tumor biology and tumor/host interactions. Systematic classification of patients coupled with therapeutic advances point to a future of improved clinical outcomes for this biologically distinct and highly aggressive pediatric malignancy.

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“…In addition, transcription factors Myb, Myc, and Prdm1 are also required for specification [42–44]. Myb directly interacts with Pax3/7 as well as Sox10 in chick, and Prdm1 directly interacts with Tfap2a and Foxd3 in fish [43–46].…”

Section: Neural Crest Specificationmentioning

confidence: 99%

Regulatory Logic Underlying Diversification of the Neural Crest

2017

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The neural crest is a transient, multipotent population of cells that arises at the border of the developing nervous system. After closure of the neural tube, these cells undergo an epithelial to mesenchymal transition to delaminate and migrate, often to distinct locations in the embryo. Neural crest cells give rise to a diverse array of derivatives including neurons and glia of the peripheral nervous system, melanocytes, and bone and cartilage of the face. A gene regulatory network (GRN) controls specification, delamination, migration, and differentiation of this fascinating cell type. With increasing technological advances, direct linkages within the neural crest GRN are being uncovered. The underlying circuitry is useful for understanding important topics such as reprogramming, evolution, and disease.

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Prdm1a directly activates foxd3 and tfap2a during zebrafish neural crest specification

Cited by 51 publications

References 66 publications

Establishing neural crest identity: a gene regulatory recipe

Establishing neural crest identity: a gene regulatory recipe

Neuroblastoma: Molecular Pathogenesis and Therapy

Regulatory Logic Underlying Diversification of the Neural Crest

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