Pre- and Post-prandial Plasma Ghrelin Levels Do Not Correlate with Satiety or Failure to Achieve a Successful Outcome after Roux-en-Y Gastric Bypass

Christou, Nicolas V.; Look, Didier; McLean, A. Peter H.

doi:10.1381/0960892054621071

Cited by 45 publications

(25 citation statements)

References 17 publications

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“…The majority of authors agree upon the fact that ghrelin is an important determinant of energy homeostasis, a peripherally secreted orexigenic hormone acting in key central pathways, with measurable levels demonstrating meal-to-meal variation. Noteworthy, to our knowledge, no study to date has demonstrated that ghrelin levels postoperatively are predictors of success in patients after LRYGB [36].…”

Section: Discussionmentioning

confidence: 95%

“…Because ghrelin levels have been shown to be low after LRYGB in some studies [20,30,[31][32][33][34][35][36], it has been proposed that lower ghrelin levels may contribute to the success of some surgical weight loss procedures, including LRYGB [14,15,20] and possibly laparoscopic adjustable gastric banding [30]. However, data have been inconsistent [10,12,15,16,25,37].…”

Section: Discussionmentioning

confidence: 99%

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Persistent Correlation of Ghrelin Plasma Levels with Body Mass Index Both in Stable Weight Conditions and during Gastric-bypass-induced Weight Loss

et al. 2008

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Background Studies done on serial changes in plasma ghrelin levels after gastric bypass (GBP) have yielded contrasting results since decreased, unchanged, or increased levels have been reported in the literature. This study investigates whether or not GBP has an inhibitory effect on fasting ghrelin levels independently of weight loss. Methods Fasting ghrelin levels were measured in 115 stable body weight females, classified as normal body weight (NW; body mass index (BMI)<25 kg/m 2 ), overweight (OW; BMI 25-30 kg/m 2 ), and obese subjects, divided in three subgroups with increasing BMI (BMI 30-40 kg/m 2 ; BMI 40-50 kg/m 2 ; BMI >50 kg/m 2 ). Results Each obese subgroup showed significantly lower ghrelin levels as compared to both NW (p<0.0001) and OW subjects (p<0.05 or 0.005); however, no significant differences were observed within the three obese subgroups. Forty-nine obese patients underwent a GBP. Plasma ghrelin, measured at 3, 6, and 12 months after GBP, significantly increased from the sixth month on (p<0.0001). When patients were classified, at each postoperative time point, according to their actual BMI, ghrelin was significantly (p=0.0002) related to postoperative BMI and not significantly different from ghrelin measured in stable body weight conditions. Conclusions Fasting ghrelin displays an inversely significant correlation with BMI in both stable body weight conditions and after GBP. No evidence was found that GBP had an effect on fasting ghrelin levels, independent of weight loss.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Persistent Correlation of Ghrelin Plasma Levels with Body Mass Index Both in Stable Weight Conditions and during Gastric-bypass-induced Weight Loss

et al. 2008

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“…Patients with optimal restriction experienced greater satiety, but there was no difference in ghrelin levels between the two groups. In RYGB patients, Christou and coworkers 121 looked at fasting plasma ghrelin in those who achieved successful weight loss (EWL 72%) and less than ideal weight loss (EWL 27%) 3 years after surgery. There was no difference between fasting or postprandial levels in the two groups and no correlation between ghrelin levels and their visual analog scale score.…”

Section: Ghrelinmentioning

confidence: 99%

Mechanisms Responsible for Excess Weight Loss after Bariatric Surgery

Ionut

Bergman

2011

J Diabetes Sci Technol

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Obesity has increased alarmingly in the United States and is increasing in many countries of the world. Because obesity is an important risk factor for type 2 diabetes and other chronic diseases, it is important to develop approaches to counter the rapid increase in adiposity. One approach is bariatric surgery, the most successful clinical intervention known for treating obesity. Surgery can result in impressive weight loss and improvement of obesity-related comorbidities. Yet the mechanisms responsible for this remarkable effect of surgery remain controversial. It is now clear that caloric restriction, per se, does not explain all the reduction in stored fat mass after surgery. A number of gastrointestinal hormones, including glucagon-like peptide (GLP)-1, peptide YY, oxyntomodulin, GLP-2, glucose-dependent insulinotropic polypeptide, ghrelin, and others, can play roles in energy homeostasis and could be involved in bariatric-surgery-related weight loss and weight loss maintenance. Vagal innervation may play a role. In addition, there may be other yet-uncharacterized factors that could participate. This review discusses the possible roles of these hormonal mechanisms in various types of bariatric surgery to help elucidate some of the potential mechanisms at play in short-term and long-term post-bariatric surgery weight loss. Understanding such mechanisms could lead to new and efficacious means to control or even reduce the epidemic of obesity.

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“…Ghrelin levels are increased with diet induced weight loss. Interestingly RYGBP has been shown to be associated with low levels of circulating ghrelin that persist at 1 and 3 years followup [42,43] . On the contrary, LASGB, VBG [44] , and antireflux surgical procedures [37,[45][46][47][48] are not associated with a decline of the circulating levels of ghrelin [42] .…”

Section: Physiology Of Lsgmentioning

confidence: 99%

Laparoscopic sleeve gastrectomy for morbid obesity

Iannelli¹

2008

WJG

128

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The incidence of obesity is steadily rising, and it has been estimated that 40% of the US population will be obese by the year 2025 if the current trend continues. In recent years there has been renewed interest in the surgical treatment of morbid obesity in concomitance with the epidemic of obesity. Bariatric surgery proved effective in providing weight loss of large magnitude, correction of comorbidities and excellent short-term and long-term outcomes, decreasing overall mortality and providing a marked survival advantage. The Laparoscopic Sleeve Gastrectomy (LSG) has increased in popularity and is currently very "trendy" among laparoscopic surgeons involved in bariatric surgery. As LSG proved to be effective in achieving considerable weight loss in the shortterm, it has been proposed by some as a sole bariatric procedure. This editorial focuses on the particular advantages of LSG in the treatment of morbid obesity.

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Pre- and Post-prandial Plasma Ghrelin Levels Do Not Correlate with Satiety or Failure to Achieve a Successful Outcome after Roux-en-Y Gastric Bypass

Cited by 45 publications

References 17 publications

Persistent Correlation of Ghrelin Plasma Levels with Body Mass Index Both in Stable Weight Conditions and during Gastric-bypass-induced Weight Loss

Persistent Correlation of Ghrelin Plasma Levels with Body Mass Index Both in Stable Weight Conditions and during Gastric-bypass-induced Weight Loss

Mechanisms Responsible for Excess Weight Loss after Bariatric Surgery

Laparoscopic sleeve gastrectomy for morbid obesity

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