Pre- and postoperative predictors of phantom limb pain

Larbig, W.; Andoh, Jamila; Huse, Ellena; Stahl-Corino, Dietlinde; Montoya, Pedro; Seltzer, Zeʼev; Flor, Herta

doi:10.1016/j.neulet.2018.11.044

Cited by 44 publications

(47 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lack of proprioceptive feedback during the use of a prosthetic leg has been linked to poor motor control, possibly leading to stump irritation that may trigger PLP [2,67]. This proposed link is partially supported by seven studies in this review which suggested that PLP was more likely to occur in people with stump pain than in those without stump pain [3,4,12,13,41,44,47]. Interestingly, Dietrich and colleagues investigated the effects of a leg prosthesis with somatosensory feedback on pain and lower limb function [68].…”

Section: Risk Factors For Phantom Limb Painmentioning

confidence: 85%

“…Lower limb amputation was positively associated with PLP (moderate to strong association) in two studies representing a total of 1450 participants [ 12 , 38 ]. Stump pain was consistently positively associated with PLP (weak to very strong association) in seven studies representing a total of 1254 participants [ 3 , 4 , 12 , 13 , 41 , 46 , 47 ]. Phantom sensations were consistently positively associated with PLP (strong to very strong association) in four studies representing a total of 1156 participants [ 12 , 13 , 42 , 48 ].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The prevalence and risk factors for phantom limb pain in people with amputations: A systematic review and meta-analysis

et al. 2020

View full text Add to dashboard Cite

Background Phantom limb pain (PLP)-pain felt in the amputated limb-is often accompanied by significant suffering. Estimates of the burden of PLP have provided conflicting data. To obtain a robust estimate of the burden of PLP, we gathered and critically appraised the literature on the prevalence and risk factors associated with PLP in people with limb amputations. Methods Articles published between 1980 and July 2019 were identified through a systematic search of the following electronic databases:

show abstract

Section: Risk Factors For Phantom Limb Painmentioning

confidence: 85%

Section: Resultsmentioning

confidence: 99%

The prevalence and risk factors for phantom limb pain in people with amputations: A systematic review and meta-analysis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…For example, research of chronic musculoskeletal pain has been focused on widespread brain alterations and less on S1 ( Lopez-Sola et al., 2017 ). In this context, the above mentioned activity could be due to a greater association of PLP with changes in sensory rather than affective processing ( Fuchs et al., 2018 ; Larbig et al., 2019 ).…”

Section: Insights On Remapping and Phantom Pain From Clinical Studiesmentioning

confidence: 99%

Brain (re)organisation following amputation: Implications for phantom limb pain

2020

Self Cite

View full text Add to dashboard Cite

Following arm amputation the region that represented the missing hand in primary somatosensory cortex (S1) becomes deprived of its primary input, resulting in changed boundaries of the S1 body map. This remapping process has been termed ‘reorganisation’ and has been attributed to multiple mechanisms, including increased expression of previously masked inputs. In a maladaptive plasticity model, such reorganisation has been associated with phantom limb pain (PLP). Brain activity associated with phantom hand movements is also correlated with PLP, suggesting that preserved limb functional representation may serve as a complementary process. Here we review some of the most recent evidence for the potential drivers and consequences of brain (re)organisation following amputation, based on human neuroimaging. We emphasise other perceptual and behavioural factors consequential to arm amputation, such as non-painful phantom sensations, perceived limb ownership, intact hand compensatory behaviour or prosthesis use, which have also been related to both cortical changes and PLP. We also discuss new findings based on interventions designed to alter the brain representation of the phantom limb, including augmented/virtual reality applications and brain computer interfaces. These studies point to a close interaction of sensory changes and alterations in brain regions involved in body representation, pain processing and motor control. Finally, we review recent evidence based on methodological advances such as high field neuroimaging and multivariate techniques that provide new opportunities to interrogate somatosensory representations in the missing hand cortical territory. Collectively, this research highlights the need to consider potential contributions of additional brain mechanisms, beyond S1 remapping, and the dynamic interplay of contextual factors with brain changes for understanding and alleviating PLP.

show abstract

“…Of the included studies, 12 were cross-sectional (Aldington et al, 2014;Bekrater-Bodmann et al, 2015;Buchheit et al, 2016;Giummarra et al, 2015;Morgan, Friedly, Amtmann, Salem, & Hafner, 2017;Poor Zamany Nejat Kermany, 2016;Rafferty, Bennett Britton, Drew, & Phillip, 2015;Razmus, Daniluk, & Markiewicz, 2017;Resnik, Ekerholm, Borgia, & Clark, 2019;Richardson, Crawford, Milnes, Bouch, & Kulkarni, 2015;Richardson, Olleveant, Crawford, & Kulkarni, 2018;Streit et al, 2015) and three were prospective, longitudinal designs recruiting inception cohorts (i.e. recruiting participants prior to amputation) (Agha, 2017;Ahmed et al, 2017;Larbig et al, 2019). Five studies evaluated populations with traumatic reasons for amputation (Aldington et al, 2014;Buchheit et al, 2016;Poor Zamany Nejat Kermany, 2016;Rafferty et al, 2015;Resnik et al, 2019), four evaluated atraumatic populations (Ahmed et al, 2017;Larbig et al, 2019;Morgan et al, 2017;Richardson et al, 2015) and six studies evaluated a combined aetiology population (Agha, 2017;Bekrater-Bodmann et al, 2015;Giummarra et al, 2015;Razmus et al, 2017;Richardson et al, 2018;Streit et al, 2015).…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Prevalence and incidence of phantom limb pain, phantom limb sensations and telescoping in amputees: A systematic rapid review

Stankevicius

Wallwork

Summers

et al. 2020

European Journal of Pain

View full text Add to dashboard Cite

Background and objective: This systematic, rapid review aimed to critically appraise and synthesize the recent literature (2014-2019) evaluating the incidence and prevalence of post-amputation phantom limb pain (PLP) and sensation (PLS). Databases and data treatment: Five databases (Medline, Embase, Emcare, PsychInfo, Web of Science) and Google Scholar were searched, with two independent reviewers completing eligibility screening, risk of bias assessment and data extraction. Results: The search identified 1,350 studies with 12 cross-sectional and 3 prospective studies included. Studies evaluated traumatic (n = 5), atraumatic (n = 4), and combined traumatic/atraumatic (n = 6) amputee populations, ranging from 1 month to 33 years post-amputation. Study heterogeneity prevented data pooling. The majority of studies had a high risk of bias, primarily due to limited generalizability. Three studies evaluated PLP incidence, ranging from 2.2% (atraumatic; 1 month) to 41% (combined; 3 months) and 82% (combined; 12 months). Only one study evaluated PLS/telescoping incidence. Across contrasting populations, PLP point prevalence was between 6.7%-88.1%, 1 to 3-month period prevalence was between 49%-93.5%, and lifetime prevalence was high at 76%-87%. Point prevalence of PLS was 32.4%-90%, period prevalence was 65% (1 month) and 56.9% (3 months), and lifetime prevalence was 87%. Telescoping was less prevalent, highest among traumatic amputees (24.6%) within a 1-month prevalence period. Variations in population type (e.g. amputation characteristics) and incidence and prevalence measures likely influence the large variability seen here. Conclusions: This review found that lifetime prevalence was the highest, with most individuals experiencing some type of phantom phenomena at some point post-amputation.

show abstract

Pre- and postoperative predictors of phantom limb pain

Cited by 44 publications

References 29 publications

The prevalence and risk factors for phantom limb pain in people with amputations: A systematic review and meta-analysis

The prevalence and risk factors for phantom limb pain in people with amputations: A systematic review and meta-analysis

Brain (re)organisation following amputation: Implications for phantom limb pain

Prevalence and incidence of phantom limb pain, phantom limb sensations and telescoping in amputees: A systematic rapid review

Contact Info

Product

Resources

About