Pre-Clinical Evaluation of Lowering Atherosclerosis Risk Factors in Hypercholesterolemic Rats and the Immunomodulating Action of Ganoderma Lucidum and Chrysanthemum Indicum Linn

Abstract

This research aimed to address cardiovascular disease, specifically atherosclerosis, by using (t= 2.969, sig. 0.013) and IgG (t= 3.865, sig. 0.003) while no significant decrease in IgA (t=1.683, sig 0.130). Comparison of the treatments using ANOVA showed significant differences between treatments in IgA (F(3,8) =8.458 , p = 0.007.) and IgG (F(3,8) =174.115, sig. <0.0001) but not significant in IgM (F(3,8) = 3.998 , p =.148). There was also significant increase in the number of lymphocytes on R. albus (t=2.659, sig. 0.019)

Effect of Ganoderma lucidum on serum lipid profiles: A systematic review and meta-analysis on animal studies

“…Six studies reported no significant association between G. lucidum consumption and TC levels. [ 30 31 33 37 44 45 ] However, some studies showed significant beneficial effects of G. lucidum on TC levels. [ 34 35 36 ]…”

“…Four studies reported that G. lucidum had a non-significant effect on LDL-C along with other lipid profile components. [ 30 31 44 46 ]…”

“…[ 34 35 ] Non-significant effect was reported in eight studies. [ 31 32 33 37 44 46 48 49 ] In seven of them non-significant effects were reported for other lipid profile components and in one study[ 49 ] it was reported only for TG levels.…”