Pre‐clinical evaluation of the osteogenic potential of bone morphogenetic protein‐2 loaded onto a particulate porcine bone biomaterial

Abstract

Bone morphogenetic protein-2 enhanced local bone formation in the rabbit maxillary sinus model following implantation using a PBM carrier.

Increased osteoinductivity and mineralization by minimal concentration of bone morphogenetic protein-2 loaded onto biphasic calcium phosphate in a rabbit sinus

“…The results of this study showed lower values of total augmented area than previous studies that have investigated the effect of BMP-2 in the same experimental model [15911]. The smaller total augmented area could be associated with characteristics of the grafted material.…”

“…Therefore, studies with a lower dose in the range 0.10–0.15 mg/mL of BMP-2 have been conducted in rabbit sinuses with various healing periods. In another previous study with 0.1 mg/mL of BMP-2, new bone formation of the BMP group was statistically greater than that of the control group [11]. Kim et al [1] reported similar data with the same concentration of BMP-2 in a previous study and the area of newly formed bone of the BMP group was significantly greater than that of the control group at weeks 2 and 4 of the healing period.…”

“…However, there are concerns that this may result in uncontrolled release and uneven distribution of the BMP. A coating method using lyophilization has been shown to have a sustained release profile in in vitro models [11], but the complicated process is a shortcoming of this method. There are no studies comparing the effect of BMP according to different loading methods to the best of our knowledge.…”

Sinus augmentation using a mini‐pig model: Effect of ceramic and allogeneic bone biomaterials

“…(). Although several animal platforms including rabbit (Yon et al., ), dog (Schlegel, Fichtner, Schultze‐Mosgau, & Wiltfang, ), mini‐pig (Terheyden et al., ), goat/sheep (Philipp et al., ), and nonhuman primates (Hanisch et al., ) have been employed to evaluate sinus augmentation protocols, the mini‐pig model presents several advantages (Lee, Fiorini, Wikesjö, & Susin, ). Due to the convenient size and disposition of the maxillary sinus, the mini‐pig features skeletal proportions that allow the use of dental implants of clinically meaningful dimensions.…”

Bone Regeneration Using N-Methyl-2-pyrrolidone as an Enhancer for Recombinant Human Bone Morphogenetic Protein-2 in a Rabbit Sinus Augmentation Model

“…The introduction of recombinant human bone morphogenetic protein-2 (rhBMP-2) was considered revolutionary in both fulfilling clinical needs and overcoming shortcomings of traditional procedures. Numerous preclinical studies have found that the use of rhBMP-2 induced exceptional bone regeneration within a short healing period [2–6]. Unfortunately, the use of rhBMP-2 is restricted to few indications (only maxillary sinus augmentation and extraction socket), due to its relatively high cost and potential complications such as extensive postoperative swelling and seroma formation [7, 8].…”