Pre-clinical Study of Marketed Polyherbal Formulations on Blood Glucose Level and Associated Parameters in Streptozotocin-induced Diabetes

Abstract

The management of diabetes mellitus involves lowering blood glucose levels with anti-diabetic drugs. Globally and nationally, the demand for herbal goods is increasing correspondingly. There have been numerous polyherbal preparations with anti-diabetic activity discovered during the past few decades. For both their antidiabetes and potential to avert diabetic complications, two different commercial polyherbal preparations were tested. For the purpose of choosing a commercial polyherbal formulation, a survey was conducted. The formulations were chosen based on their similarity in terms of their constituents, their estimated efficacy, how frequently they were distributed, and their price range. STZ-induced diabetic rats were utilized as a model and metformin was the standard medication for evaluating the antidiabetic activity. Selected polyherbal formulations, including formulation A and formulation B, demonstrated effective anti-diabetic action. In comparison to diabetic control groups, polyherbal formulations meaningfully decreased glucose levels in diabetic rat’s blood and other diabetic complications metrics such as serum Serum glutamic oxaloacetic transaminase (SGOT), Serum glutamate pyruvate transaminase (SGPT), triglyceride, and cholesterol, as a marker for liver problems, and organ weight variation.